TY  - JOUR
T1  - The relationship between endothelial activation and stress index with survival and early mortality in acute myeloid leukemia
TT  - Akut miyeloid lösemide endotel aktivasyonu ve stres indeksi ile sağkalım ve erken mortalitenin ilişkisi
AU  - Demirci, Ufuk
AU  - Umit, Elif
AU  - Aslan, Erge
AU  - Alp Kırkızlar, Tuğcan
AU  - Kırkızlar, Hakkı Onur
AU  - Demir, Ahmet Muzaffer
PY  - 2025
DA  - December
Y2  - 2025
DO  - 10.19161/etd.1620976
JF  - Ege Tıp Dergisi
JO  - EJM
PB  - Ege University
WT  - DergiPark
SN  - 1016-9113
SP  - 606
EP  - 611
VL  - 64
IS  - 4
LA  - en
AB  - Aim: The Endothelial Activation and Stress Index (EASIX) score is used as a marker of endothelial damage and used to predict acute graft-versus-host disease and sinusoidal obstruction syndrome. We wanted to evaluate the effects of EASIX, modified EASIX (mEASIX) and sepsis modified EASIX (sEASIX) on early mortality and overall survival (OS) in patients with acute myeloid leukemia.Materials and Methods: We reviewed patients diagnosed and followed up with Acute Myeloid Leukemia (AML) in our Hematology Department, retrospectively. Patients between 18 -70 years of age and who were administered 7+3 (7 days cytarabine, and 3 days anthracycline) chemotherapy protocol (except acute promyelocytic leukemia) were included. EASIX, mEASIX and sEASIX scores of the patients, both at the time of diagnosis and at the end of the 4th week, were calculated.Results: Seventy-five patients were included in the study. The mean age was 49.05 (19-68) years and 41% were alive. EASIX and mEASIX scores measured both at the time of diagnosis and at the end of induction therapy were found to be significantly associated with early mortality (p=0.01, p
KW  - Endothelial dysfunction
KW  - Acute myeloid leukemia
KW  - Early mortality
N2  - Amaç: Endotelyal Aktivasyon ve Stres İndeksi (EASIX) skoru, endotel hasarının bir belirteci olarak ve akut greft-versus-host hastalığı ile sinüzoidal obstrüksiyon sendromunu öngörmek için kullanılır. Bu çalışmada, EASIX, modifiye EASIX (mEASIX) ve sepsis modifiye EASIX (sEASIX) skorlarının akut miyeloid lösemi hastalarında erken mortalite ve genel sağkalım (OS) üzerindeki etkilerini değerlendirmek amaçlanmıştır.Gereç ve Yöntem:  Gereç ve Yöntem: Hematoloji kliniğimizde Akut Miyeloid Lösemi (AML) tanısı konulan ve takibi yapılan hastaları retrospektif olarak inceledik. Çalışmaya 18-70 yaş aralığında, 7+3 (7 gün sitarabin ve 3 gün antrasiklin) kemoterapi protokolü uygulanan (akut promiyelositik lösemi hariç) hastalar dahil edildi. Hastaların tanı anında ve dördüncü haftanın sonundaki EASIX, mEASIX ve sEASIX skorları hesaplandı.Bulgular:  Çalışmaya 75 hasta dahil edildi. Ortalama yaş 49,05 (19-68) yıldı ve %41'i hayattaydı. Hem tanı anında hem de indüksiyon tedavisinin sonunda ölçülen EASIX ve mEASIX skorlarının erken mortalite (p=0,01, p
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UR  - https://doi.org/10.19161/etd.1620976
L1  - https://dergipark.org.tr/en/download/article-file/4525530
ER  -