TY  - JOUR
T1  - Uçucu Yağların ve Bileşenlerinin Antikanser Etki Mekanizmalarının Değerlendirilmesi
TT  - Evaluation of Anticancer Effect Mechanisms of Essential Oils and Their Components
AU  - Erdoğan, Ayşe
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.35193/bseufbd.1622844
JF  - Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi
PB  - Bilecik Seyh Edebali University
WT  - DergiPark
SN  - 2458-7575
SP  - 748
EP  - 762
VL  - 12
IS  - 2
LA  - tr
AB  - Antikanser ajan olarak yeni etken madde olarak doğal bitkisel ürünlerin araştırılması günümüzde çok hızlı ilerleyen ve oldukça dikkat çeken araştırma konularından biridir. Son yıllarda, uçucu yağların kanser tedavisindeki etkilerini değerlendiren çalışmaların sayısı önemli ölçüde artmış ve hız kazanmıştır. Uçucu yağ bileşenleri arasında monoterpenler, seskiterpenler, oksijenli monoterpenler, oksijenli seskiterpenler ve fenolikler bileşikler yer almaktadır. Bu derlemede farklı kanser hücrelerindeki uçucu yağların ve bileşenlerinin hangi hücresel etki mekanizmaları kullanarak antikanser ajan olarak değerlendirilebileceğini gösteren çalışmalara değinilmiştir. Uçucu yağlar ve bileşenlerinin kanser hücrelerini apoptoza yönlendirerek, hücre döngüsünü duraksatarak, antimetastatik ve antianjiyogenik etki göstererek, reaktif oksijen türlerinin ve reaktif azot türlerinin (ROT/RNS) miktarını arttırarak ve DNA tamir mekanizmalarını uyararak antiproliferatif aktivite gösterdikleri yapılan çalışmalar ile ortaya konmuştur. Uçucu yağ ve bileşenlerinin Süperoksit dismutaz (SOD), katalaz, glutatyon peroksidaz ve glutatyon reduktaz gibi detoksifikasyon enzimlerinin aktiviteleri üzerinde de etki gösterdikleri yapılan çalışmalarla gösterilmiştir.
KW  - Antikanser Mekanizmalar
KW  - Uçucu Yağlar
KW  - Detoksifikasyon Enzimleri
KW  - Apoptoz
KW  - Hücre Döngüsünün Durdurulması
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UR  - https://doi.org/10.35193/bseufbd.1622844
L1  - https://dergipark.org.tr/en/download/article-file/4533721
ER  -