TY  - JOUR
T1  - Can hydroxychloroquine and azithromycin combination cause cardiac rhythm disturbances in children with COVID-19 pneumonia?
TT  - COVID-19 pnömonisi olan çocuklarda Hidroksiklorokin ve azitromisin beraber kullanımı kardiyak ritim bozukluklarına neden olur mu?
AU  - Geçkalan, Damla
AU  - Özdemir, Rahmi
AU  - Yılmaz, Yasin
AU  - Çelik, Cemile Hilal
AU  - Demir, Batuhan Berk
AU  - Tunç, Yeşim
PY  - 2025
DA  - March
Y2  - 2025
DO  - 10.32322/jhsm.1625339
JF  - Journal of Health Sciences and Medicine
JO  - J Health Sci Med /JHSM /jhsm
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2636-8579
SP  - 308
EP  - 312
VL  - 8
IS  - 2
LA  - en
AB  - Aims: At the beginning of the COVID-19 pandemic; it has been shown that receiving hydroxychloroquine and azithromycin treatment decrease viral carriage of coronavirus in patients. In this study, we aimed to evaluate electrocardiography (ECG) abnormalities in pediatric patients with COVID-19 pneumonia receiving combined therapy with hydroxychloroquine and azithromycin.Methods: In this study; ECG and laboratory parameters of 24 children with COVID-19 pneumonia who were treated with hydroxychloroquine and azithromycin at Health Sciences University between June 2020 and November 2020 were analyzed retrospectively. P wave dispersion (PWd), QT interval (QT), QT dispersion (QTd), QTc interval (QTc), QTc dispersion (QTcd), Tpeak-Tend interval (Tp-e), Tp-e dispersion (Tp-ed), Tp-e/QT, Tp-Te/QTc ratios were evaluated with 12 lead ECG. ECG parameters and QTc interval were compared before and after (5 days) the treatment.Results: The mean age was 13±4.5 years and 62.5% were female. Median hospitalization length was 6 days. There was no statistically significant difference between the PWd, QT and QTc interval, QTd, QTcd, Tp-e interval, Tp-e dispersion, Tp-e/QT, Tp-e/QTd measurements and ratios of the before and after treatment. A significant difference was found for the decrease in hearth rate in regard to the measurement before and after the treatment. Conclusion: In our study, there were no rhythm problems which were observed on ECG in pediatric patients receiving hydroxychloroquine and azithromycin combination therapy for COVID-19 pneumonia. We also found that laboratory parameters were not specific for COVID-19 pneumonia in children.
KW  - Azithromycin
KW  - COVID-19
KW  - D-dimer
KW  - hydroxychloroquine
KW  - side effects
KW  - QTc prolongation
N2  - GirişCOVID-19 pandemisinin başlangıcında; hidroksiklorokin ve azitromisin tedavisi almanın hastalarda koronavirüs viral taşıyıcılığını azalttığı gösterilmiştir. Bu çalışmada, hidroksiklorokin ve azitromisin ile kombine tedavi alan COVID-19 pnömonili çocuk hastalarda elektrokardiyografi [EKG] anormalliklerini değerlendirmeyi amaçladık.YöntemlerBu çalışmada; Haziran 2020 - Kasım 2020 tarihleri arasında Sağlık Bilimleri Üniversitesi'nde hidroksiklorokin ve azitromisin ile tedavi edilen COVID-19 pnömonili 24 çocuğun EKG ve laboratuvar parametreleri retrospektif olarak analiz edilmiştir. P dalgası dispersiyonu [PWd], QT aralığı [QT], QT dispersiyonu [QTd], QTc aralığı [QTc], QTc dispersiyonu [QTcd], Tpeak-Tend aralığı [Tp-e], Tp-e dispersiyonu [Tp-ed], Tp-e/QT, Tp-Te/QTc oranları 12 derivasyonlu EKG ile değerlendirildi. EKG parametreleri ve QTc aralığı tedaviden önce ve sonra [5 gün] karşılaştırıldı.SonuçOrtalama yaş 13 ± 4,5 yıldı ve %62,5'i kızdı. Medyan hastanede yatış süresi 6 gündü.  Tedavi öncesi ve sonrası PWd, QT ve QTc intervali, QTd, QTcd, Tp-e intervali, Tp-e dispersiyonu, Tp-e/QT, Tp-e/QTd ölçümleri ve oranları arasında istatistiksel olarak anlamlı bir fark yoktu [p>0.05]. Tedavi öncesi ve sonrasında sadece kalp hızındaki azalma istatistiksel olarak anlamlı bulunmuştur [p
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UR  - https://doi.org/10.32322/jhsm.1625339
L1  - https://dergipark.org.tr/en/download/article-file/4545005
ER  -