TY - JOUR T1 - Association of sarcopenia with age-related macular degeneration in the very elderly TT - Çok yaşlılarda sarkopeni ile yaşla ilişkili makula dejenerasyonu arasındaki ilişki AU - Katipoğlu, Zeynep AU - Katipoğlu, Bilal AU - Turan, Meydan PY - 2025 DA - June Y2 - 2025 DO - 10.17826/cumj.1625475 JF - Cukurova Medical Journal JO - Cukurova Med J PB - Cukurova University WT - DergiPark SN - 2602-3032 SP - 341 EP - 346 VL - 50 IS - 2 LA - en AB - Purpose: The aim of this study was aimed to investigate the association between age-related macular degeneration and sarcopenia in the oldest-old population, constituting individuals aged ≥80 years.Material and Methods: This retrospective study was conducted in the ophthalmology and geriatric departments of a training and research hospital in 2023 and 2024. Participants aged ≥80 years who were admitted to the ophthalmology outpatient clinic for any reason were included in the study.Results: The study population comprised 311 individuals aged 80 years or older and the prevalence of age-related macular degeneration was 20.5% (n=64). The mean age of the patients diagnosed with age-related macular degeneration (AMD) was 85.9 years (±3.8), while the mean age of the control group was 85.8 years (±3.9). Of the patients diagnosed with age-related macular degeneration, 34 were female and 30 were male. The Deyo-Charlson Comorbidity Index (D-CCI) values were 1.77 in the age-related macular degeneration group and 1.85 in the control group. The prevalence of sarcopenia was significantly higher in patients with age-related macular degeneration (89.1% vs. 52.6%). Conclusion: This study demonstrates that sarcopenia is independently associated with age-related macular degeneration in the oldest-old population. These findings highlight the significance of sarcopenia management in the prevention and management of age-related macular degeneration. KW - Sarcopenia KW - Age-related macular degeneration KW - Oxidative stress KW - Inflammation KW - Older adult N2 - Amaç: Bu çalışmada yaşa bağlı makula dejenerasyonu ile sarkopeni arasındaki ilişki en yaşlı popülasyonda (80 yaş ve üzeri) araştırılmıştır.Gereç ve Yöntem: Bu retrospektif çalışma, 2023-2024 yılları arasında bir eğitim araştırma hastanesinin oftalmoloji ve geriatri bölümünde yürütülmüştür. Herhangi bir nedenle oftalmoloji polikliniğine başvuran 80 yaş ve üzeri katılımcılar bu çalışmaya dahil edilmiştir.Bulgular: Çalışma popülasyonu 80 yaş ve üzeri 311 bireyden oluşmuştur ve yaşa bağlı makula dejenerasyonunun yaygınlığı %20,5'tir (n=64). Yaşa bağlı makula dejenerasyonu olan hastaların yaş ortalaması 85.9 (±3.8) iken kontrol grubunun yaş ortalaması 85.8(±3.9) idi. Yaşa bağlı makula dejenerasyonu olan hastaların 34 ü kadın, 30 u erkekti. Deyo-Charlson comorbidity index (D-CCI) değerleri yaşa bağlı makula dejenerasyonu grubunda 1.77 iken kontrol grubunda 1.85 idi. Sarkopeni prevalansının yaşa bağlı makula dejenerasyonu hastalarında belirgin şekilde daha yüksek olduğu gözlemlendi (%89,1'e karşı %52,6). Sonuç: Çalışmamız, sarkopeninin en yaşlı bireylerde yaşa bağlı makula dejenerasyonu ile ilişkili bağımsız bir değişken olduğunu göstermektedir. Bu bulgular, sarkopeni yönetiminin yaşa bağlı makula dejenerasyonunun önlenmesi ve yönetimindeki önemini vurgulamaktadır. CR - Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392:1147-59. CR - Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022;51:afac220. CR - von Haehling S, Morley JE, Anker SD. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle. 2010;1:129-33.. CR - Sayer AA, Cruz-Jentoft A. 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Autophagy. 2013;9:973-84. UR - https://doi.org/10.17826/cumj.1625475 L1 - https://dergipark.org.tr/en/download/article-file/4545585 ER -