TY  - JOUR
T1  - Formulation and characterisation of curcumin loaded  PLGA-Tf nanoparticle for increasing the availability of  drug in the brain for the management of parkinson’s  disease
AU  - Verma, Deepika
AU  - Upadhyaya, Kumud
PY  - 2025
DA  - March
DO  - 10.12991/jrespharm.1626402
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 52
EP  - 64
VL  - 29
IS  - 1
LA  - en
AB  - Curcumin, an extract derived from Curcuma longa, boasts a myriad of medicinal applications. In our current research endeavour, we embarked on the formulation of curcumin nanoparticles via the meticulous micro emulsion precursor method, employing the Box-Behnken 32-level design approach. This involved the manipulation of three independent variables, namely, PLGA-Tf-curcumin concentration, stirring speed, and the concentration of the emulsifying agent (span 80). Our investigation revealed that all three independent variables wielded discernible influence over two crucial dependent variables: encapsulation efficiency (EE) and nanoparticle size. It was against this backdrop that we meticulously prepared a total of seventeen formulations. Among this array, formulation F3 emerged as the best to its remarkable EE (99.7±0.2) and a particle size of 214.7 nm. Delving further into our analysis, we scrutinized additional parameters, including drug content (99.7%) and cumulative percentage release (exceeding 99% within a span of 36 hours), both of which yielded highly favourable results. To elucidate the release kinetics, we harnessed the Zero Order, Higuchi, and Korsmeyer-Peppas kinetic models, each revealing an R-squared (R2) value remarkably close to unity. This signifies an exceptionally controlled and diffusion-driven drug release pattern, manifesting in a spherical manner. In this comprehensive assessment, we also scrutinized various other facets, including λmax (wavelength of maximum absorption), particle size distribution, X-ray diffraction, and FTIR analysis. Collectively, these analytical results reinforced the robust authenticity of our study.
KW  - Box-Behnken 32-level design
KW  - PLGA-Tf-curcumin concentration
KW  - encapsulation efficiency
KW  - Higuchi model
KW  - X-ray diffraction
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UR  - https://doi.org/10.12991/jrespharm.1626402
L1  - https://dergipark.org.tr/en/download/article-file/4549807
ER  -