TY  - JOUR
T1  - FABRICATION OF POLYVINYL ALCOHOL NANOFIBROUS WEBS CONTAINING MOMETASONE FUROATE MONOHYDRATE AND MELATONIN LOADED SILICA XEROGELS FOR TOPICAL DRUG DELIVERY: IN VITRO RELEASE STUDY
TT  - TOPİKAL İLAÇ SALIMI İÇİN MOMETAZON FUROAT MONOHIDRAT VE MELATONİN  YÜKLÜ SİLİKA KSEROJEL İÇEREN POLİVİNİL ALKOL NANOLİF  MEMBRAN ÜRETİMİ: IN VITRO SALIM ÇALIŞMASI
AU  - Karagüzel Kayaoğlu, Burçak
AU  - Palak, Handan
AU  - Gürbüz Yurtsever, Aslı
AU  - Kalaoğlu Altan, Özlem İpek
AU  - Erdal, Meryem Sedef
PY  - 2025
DA  - June
Y2  - 2025
DO  - 10.7216/teksmuh.1626996
JF  - Tekstil ve Mühendis
PB  - Tekstil Mühendisleri Odası
WT  - DergiPark
SN  - 1300-7599
SP  - 95
EP  - 104
VL  - 32
IS  - 138
LA  - en
AB  - A key approach to the controlled release of bioactive molecules is the development of drug delivery systems that minimize side effects and precisely regulate drug release. A strategy for enhancing the drug release properties of drug delivery systems involves loading drugs into a carrier before their incorporation into the system. Xerogels can be utilized since they are porous, and can be synthesized through ambient pressure drying of precursor wet-gels, offering a cost-effective, facile, and sustainable approach. In this study, polyvinyl alcohol (PVA)/drug loaded-silica xerogel nanofibrous webs were fabricated via electrospinning. Xerogels were synthesized via sol-gel polymerization, loaded with mometasone furoate monohydrate and melatonin, then incorporated into PVA solutions and processed into PVA/xerogel/drug nanofibrous webs. The webs were characterized in terms of their morphological and chemical properties via scanning electron microscope and Fourier transform infrared spectrometer, respectively, and as well as drug release profiles. Morphological analysis confirmed the successful incorporation of drug-loaded xerogels within nanofibers without significant change in morphological structure, while chemical analysis identified distinct peaks corresponding to the specific bands of PVA, xerogel, and drugs. In vitro drug release studies demonstrated that the release of MLT was 50.289% ± 0.462% and 55.080% ± 2.955% for the 1:1 and 1:2 MLT: Xerogel formulations, respectively, whereas the control formulation (1:0 MLT: Xerogel) exhibited a release of 66.295% ± 3.293% at first 24h. The presence of xerogel resulted in a slower MLT release compared to the xerogel-free formulation. The findings highlight the potential of xerogel-incorporated nanofibrous webs as effective carriers for controlled topical drug delivery applications, i.e., wound dressing.
KW  - Topical drug delivery system
KW  - xerogel
KW  - mometasone furoate monohydrate
KW  - melatonin
KW  - electrospinning
KW  - PVA
N2  - Biyolojik aktif moleküllerin kontrollü salımına yönelik temel yaklaşımlardan biri, yan etkileri en aza indirirken ilaç salımını hassas bir şekilde düzenleyen ilaç salım sistemlerinin geliştirilmesidir. İlaç salım sistemlerinin ilaç salım özelliklerini iyileştirmeye yönelik stratejilerden biri, ilaçların sistem içine dahil edilmeden önce bir taşıyıcıya yüklenmesidir. Gözenekli yapıları ve öncül ıslak jellerin ortam basıncında kurutulmasıyla sentezlenebilmeleri nedeniyle, kserojeller düşük maliyetli, kolay uygulanabilir ve sürdürülebilir bir yöntem sunarak ilaç taşıma sistemlerinde kullanılabilirler. Bu çalışmada, elektro-eğirme yöntemi kullanılarak polivinil alkol (PVA)/ilaç yüklü silika kserojel nanolif yüzeyler üretilmiştir. Kserojeller sol-jel polimerizasyonu yoluyla sentezlenmiş, mometazon furoat monohidrat ve melatonin ile yüklenmiş, ardından PVA çözeltilerine dahil edilerek PVA/kserojel/ilaç nanolif yüzeyler geliştirilmiştir. Üretilen yüzeylerin morfolojik ve kimyasal özellikleri sırasıyla taramalı elektron mikroskobu ve Fourier dönüşümlü kızılötesi spektrometresi ile karakterize edilmiş, ayrıca ilaç salım profilleri değerlendirilmiştir. Morfolojik analizler, ilaç yüklü kserojellerin nanoliflere başarılı bir şekilde entegre edildiğini ve morfolojik yapıda belirgin bir değişiklik olmadığını doğrulamıştır. Kimyasal analizler ise PVA, kserojel ve ilaçlara özgü belirgin piklerin varlığını göstermiştir. In vitro ilaç salım çalışmaları, 24 saat sonunda MLT salımının 1:1 ve 1:2 MLT:kserojel formülasyonları için sırasıyla %50.289 ± %0.462 ve %55.080 ± %2.955 olduğunu, kontrol formülasyonu (1:0 MLT:kserojel) için ise %66.295 ± %3.293 salım gerçekleştiğini göstermiştir. Kserojel varlığı, kserojel içermeyen formülasyona kıyasla MLT’nin daha yavaş salınmasını sağlamıştır. Elde edilen bulgular, kserojel içeren nanolifli ağların kontrollü topikal ilaç salımı uygulamaları, örneğin yara örtüleri, için etkili taşıyıcılar olarak potansiyelini ortaya koymaktadır.
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UR  - https://doi.org/10.7216/teksmuh.1626996
L1  - https://dergipark.org.tr/en/download/article-file/4552266
ER  -