@article{article_1627726, title={Effects of Vertebrate Insulin Hormone on Major Hemolymph Proteins and Ovarium Development in The Silkworm Bombyx mori Pupal Stage}, journal={Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi}, volume={28}, pages={1357–1370}, year={2025}, DOI={10.18016/ksutarimdoga.vi.1627726}, author={Ordu, Tugce and Yılmaz, Kübra and Göncü, Ebru}, keywords={Bombyx mori, Hemolymph, Ovarium, Insulin, Protein}, abstract={Insulin, released from the islets of Langerhans in the pancreas, regulates sugar metabolism and plays a key role in growth, differentiation, metabolism, and apoptosis in both vertebrates and invertebrates. Vertebrate insulin affects anabolic metabolism by activating glucose uptake and conversion while inhibiting glycogen degradation. The first insulin-like peptide (ILP) identified in invertebrates was bombyxin from Bombyx mori, which regulates growth, metabolism, and egg development, and is homologous to mammalian insulin. In insects, hemolymph consists of plasma and hemocytes, which are essential for defense against microorganisms and antigens. All events, such as the transportation of hormones and nutrients to target cells and the sending of waste to excretory organs, occur through hemolymph. The key organs that play a role in reproductive physiology in female insects are the fat body and the ovary. Some proteins synthesized by fat body cells are transported to the ovary via hemolymph during the pupal period and play a role in egg development. Due to different physiological processes, the content and amount of hemolymph proteins change in larval, pupal, and adult stages. In this study, vertebrate insulin was injected into B. mori female pupae on different days, and its effects on ovarian development and major hemolymph proteins were investigated. For this purpose, histological and electrophoretic methods were used. Findings showed that the vertebrate hormone insulin causes changes in the relative abundance of essential proteins in the ovary and hemolymph of female B. mori pupae.}, number={5}, publisher={Kahramanmaras Sutcu Imam University}