TY - JOUR T1 - Neuroprotective Effects of Dexpanthenol Against Chest Trauma-Induced Brain Injury in Rats AU - Taşan, Şerife AU - Aşcı, Sanem AU - Aşçı, Halil PY - 2025 DA - September Y2 - 2025 DO - 10.17343/sdutfd.1629663 JF - Medical Journal of Süleyman Demirel University JO - Med J SDU PB - Süleyman Demirel University WT - DergiPark SN - 1300-7416 SP - 184 EP - 190 VL - 32 IS - 3 LA - en AB - Objective: Chest trauma-induced brain injury (CTB) occurs as a result of the formation of inflammatory markers in the lung and blood. Vitamin B5, derived from dexpanthenol (DEX), has antioxidant, anti-inflammatory, and antiapoptotic properties. This study aimed to investigate the protective effects of DXP on CTB.Materials and methods: Forty Wistar Albino males were divided into four groups as sham, CTB (Dropping a 200g weight from a height of 1 meter onto the anterior chest wall), CTB+DXP (500mg/kg, ip), and DXP. After 48 hours, rats were sacrificed under anesthesia, and the brain tissues were put into 10% formaldehyde solution for histopathological and immunohistochemical examination.Results: In the CTB group, rats exhibited significant hemorrhage, increased TNF-α, Cas-3, and decreased MBP expressions in the brain compared to the control group. DXP treatment significantly reducted hemorrhage areas and reversed immunoexpressions. Conclusion: CTB may develop in brain tissue by causing inflammation, apoptosis, and myelin sheath damage. These adverse effects can be reversed with DXP treatment. KW - acute cheast trauma KW - brain KW - dexpanthenol KW - inflammation KW - apoptosis CR - 1. Požgain Z, Kristek D, Lovrić I, Kondža G, Jelavić M, Kocur J, et al. Pulmonary contusions after blunt chest trauma: clinical significance and evaluation of patient management. Eur J Trauma Emerg Surg 2018;44:773–7. CR - 2. Lewis BT, Herr KD, Hamlin SA, Henry T, Little BP, Naeger DM, et al. 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