TY  - JOUR
T1  - Chemical composition of endemic Hypericum bilgehan-bilgilii Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials
AU  - Barak, Timur Hakan
AU  - Servi, Hüseyin
AU  - Şen, Ali
AU  - Ertekin, Simge
AU  - Türker, Hüseyin
AU  - Türkyılmaz Ünal, Bengü
AU  - İşlek, Cemil
PY  - 2025
DA  - October
Y2  - 2025
JF  - Trakya University Journal of Natural Sciences
JO  - Trakya Univ J Nat Sci
PB  - Trakya University
WT  - DergiPark
SN  - 2528-9691
SP  - 127
EP  - 134
VL  - 26
IS  - 2
LA  - en
AB  - Hypericum L. is a significantly important genus for flora of Türkiye due to its richness in phytochemicals possessing medicinal and cosmetic benefits. The essential oil composition and biological activities of Hypericum bilgehan-bilgilii Basköse & Savran (HEO) were analysed for the first time in the present study. The volatile oil of the whole parts of H. bilgehan-bilgilii was obtained by hydrodistillation with Clevenger-type apparatus. The chemical composition was analyzed by GC-MS using non-polar column. α-glucosidase and 5-lipoxygenase inhibitory, cytotoxic, and DPPH radical scavenging activities were investigated. Forty-eight components were identified and represented 97.3% of the whole constituents. Interestingly, the major volatiles: 1-(2,4,5-trimethoxyphenyl)butan-1-one (27.7%) and 3-Methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one (11.2%) were detected for the first time in Hypericum essential oils. The oil exhibited a significant activity against the 5-lipoxygenase enzyme with an IC50 value of 39 µg/mL. Cytotoxicity potential of HEO was investigated, at different concentrations, towards four cell lines and, IC50 values underlies mild cytotoxicity. These results indicated that H. bilgehan-bilgilii essential oil may be considered as a valuable source for bioactive ingredients and anti-inflammatory agents.
KW  - Aromatherapy
KW  - Gas Chromatography-Mass Spectrometry
KW  - GC-FID
KW  - Bioactivity
KW  - Hypericum bilgehan-bilgilii
N2  - Hypericum cinsi, tıbbi ve kozmetik faydaları olan fitokimyasallar bakımından zengin olması nedeniyle Türkiye florası için önemli bir cinstir. Hypericum bilgehan-bilgilii Basköse & Savran'ın (HEO)’nin uçucu yağ bileşimi ve biyolojik aktiviteleri bu çalışmada ilk kez analiz edilmiştir. Hypericum bilgehan-bilgilii tüm kısımlarının uçucu yağı, Clevenger tipi aparatla hidrodistilasyon yoluyla elde edilmiştir. Kimyasal bileşim, polar olmayan kolon kullanılarak GC-MS ile analiz edilmiştir. α-glukozidaz ve 5-lipoksijenaz inhibitör, sitotoksik ve DPPH radikal süpürücü aktiviteleri araştırılmıştır. Kırk sekiz bileşen tanımlanmış ve tüm bileşenlerin %97,3'ünü temsil etmiştir. İlginç bir şekilde, majör uçucular: 1-(2,4,5-trimetoksifenil)bütan-1-on (%27,7) ve 3-Metil-1-(2,4,6-trihidroksifenil)bütan-1-on (%11,2) Hypericum uçucu yağlarında ilk kez tespit edilmiştir. Yağ, 39 µg/mL'lik bir IC50 değeriyle 5-lipoksijenaz enzimine karşı önemli bir aktivite göstermiştir. HEO'nun sitotoksisite potansiyeli, farklı konsantrasyonlarda, dört hücre hattına karşı araştırılmış ve IC50 değerleri hafif sitotoksisitenin varlığını göstermiştir. Bu sonuçlar, H. bilgehan-bilgilii uçucu yağının biyoaktif bileşenler ve anti-inflamatuar ajanlar için değerli bir kaynak olarak kabul edilebileceğini göstermiştir.
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UR  - https://dergipark.org.tr/en/pub/trkjnat/issue//1634620
L1  - https://dergipark.org.tr/en/download/article-file/4585963
ER  -