@article{article_1636484, title={Therapeutic Potential of Irisin in Ovarian Torsion-Detorsion: Mitigating Oxidative Stress and Inflammatory Response}, journal={Clinical and Experimental Health Sciences}, volume={15}, pages={434–439}, year={2025}, DOI={10.33808/clinexphealthsci.1636484}, author={Güler, Mustafa Can and Bircan, Burak and Eraslan, Ersen and Ekinci Akdemir, Fazile Nur and Yazici, Şahin and Güzel, Derya and Öztürk, Deniz and Polat, Elif and Tanyeli, Ayhan}, keywords={Ovarian torsion-detorsion, ischemia-reperfusion injury, irisin, oxidative stress, inflammatory response}, abstract={Objective: Ovarian torsion (OT) is a critical gynecological emergency marked by partial or complete rotation of the ovary around its ligamentous supports, resulting in impaired blood flow and potential ischemic injury or necrosis if not treated promptly. This study explores the potential of irisin in mitigating ischemia-reperfusion (I/R) injury following ovarian torsion-detorsion (T/D), with a focus on oxidative stress and inflammatory mediators. Methods: Twenty-four female Sprague-Dawley rats were allocated into three groups: Sham, T/D, and irisin 10 μg/kg. Oxidative stress markers—total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA), and myeloperoxidase (MPO)—were measured to assess tissue damage. Antioxidant parameters, including superoxide dismutase (SOD) activity and total antioxidant status (TAS) were evaluated. Serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) were analyzed to assess systemic inflammation and irisin’s modulatory role. Results: The T/D group showed elevated MPO and MDA levels relative to the sham group (p <.05), alongside significant reductions in SOD activity and TAS levels (p <.05). Irisin administration reversed these imbalances, decreasing MPO and MDA levels and enhancing SOD and TAS levels (p <.05 vs. T/D group). TNF-α and IL-1β levels, which were significantly elevated in the T/D group, were reduced by irisin treatment (p < .05 vs. T/D group), indicating its anti-inflammatory efficacy. Conclusion: The findings support the potential of irisin as a therapeutic agent for mitigating oxidative stress and inflammation in ovarian I/R injury. Irisin may offer clinical benefits in preserving ovarian function during conditions related to T/D.}, number={2}, publisher={Marmara University}