TY  - JOUR
T1  - Therapeutic Potential of Irisin in Ovarian Torsion-Detorsion: Mitigating Oxidative Stress and Inflammatory Response
TT  - İrisinin Over Torsiyon-Detorsiyonundaki Terapötik Potansiyeli: Oksidatif Stres ve İnflamatuar Yanıtta Azalma
AU  - Tanyeli, Ayhan
AU  - Güler, Mustafa Can
AU  - Bircan, Burak
AU  - Eraslan, Ersen
AU  - Ekinci Akdemir, Fazile Nur
AU  - Yazici, Şahin
AU  - Güzel, Derya
AU  - Öztürk, Deniz
AU  - Polat, Elif
PY  - 2025
DA  - June
Y2  - 2025
DO  - 10.33808/clinexphealthsci.1636484
JF  - Clinical and Experimental Health Sciences
PB  - Marmara University
WT  - DergiPark
SN  - 2459-1459
SP  - 434
EP  - 439
VL  - 15
IS  - 2
LA  - en
AB  - Objective: Ovarian torsion (OT) is a critical gynecological emergency marked by partial or complete rotation of the ovary around its ligamentous supports, resulting in impaired blood flow and potential ischemic injury or necrosis if not treated promptly. This study explores the potential of irisin in mitigating ischemia-reperfusion (I/R) injury following ovarian torsion-detorsion (T/D), with a focus on oxidative stress and inflammatory mediators.Methods: Twenty-four female Sprague-Dawley rats were allocated into three groups: Sham, T/D, and irisin 10 μg/kg. Oxidative stress markers—total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA), and myeloperoxidase (MPO)—were measured to assess tissue damage. Antioxidant parameters, including superoxide dismutase (SOD) activity and total antioxidant status (TAS) were evaluated. Serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) were analyzed to assess systemic inflammation and irisin’s modulatory role.Results: The T/D group showed elevated MPO and MDA levels relative to the sham group (p
KW  - Ovarian torsion-detorsion
KW  - ischemia-reperfusion injury
KW  - irisin
KW  - oxidative stress
KW  - inflammatory response
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UR  - https://doi.org/10.33808/clinexphealthsci.1636484
L1  - https://dergipark.org.tr/en/download/article-file/4594566
ER  -