@article{article_1643639, title={Nephroprotective Effect of Apilarnil in Acetaminophen-Induced Acute Kidney Injury Model}, journal={Istanbul Gelisim University Journal of Health Sciences}, pages={399–410}, year={2026}, DOI={10.38079/igusabder.1643639}, url={https://izlik.org/JA22DJ49RN}, author={Bıçakçı, Nurcan and Bıçakçı, Sercan and Karaboğa, İhsan}, keywords={Acetaminophen, apilarnil, acute kidney injury}, abstract={<p> <span> <strong>Aim: </strong> High-dose and long-term acetaminophen (paracetamol; PAR) use can cause acute and chronic kidney damage. It was reported that apilarnil (AP), an apitherapy product obtained from drone larvae, has high antioxidative and anti-inflammatory effects. In this study, the effect of apilarnil on kidney tissue damage, oxidative status, and inflammation in an acetaminophen-induced renal injury model was investigated. </span> </p> <p> <span> <strong>Method: </strong> A total of 32 adult male Wistar albino rats were used in this study. Rats were divided into 4 groups as control, paracetamol (PAR), paracetamol+apilarnil (PAR+AP) and apilarnil (AP) groups. A dose of 600 mg/kg PAR was used to create the acute kidney injury model. AP was administered at a dose of 0.8 mg/kg. Kidney tissue histopathology was evaluated with the hematoxylin-eosin (H&E) staining method. Renal tumor necrosis factor α (TNF-α) expression was determined by the indirect immunohistochemical method. Renal glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) levels were determined by the ELISA method. </span> </p> <p> <span> <strong>Results: </strong> PAR administration caused an increase in MDA level in kidney tissue, while antioxidant enzyme levels of SOD, CAT and GPx decreased. PAR also caused an increase in renal TNF-α immunohistochemical expression. AP treatment provided a significant decrease in MDA level, while GPx and SOD levels increased. AP treatment also provided a decrease in renal TNF-α expression and tubular damage score. </span> </p> <p> <span> <strong>Conclusion: </strong> This study is the first report showing that AP prevents paracetamol-induced renal damage. AP may be an option that can be used for the treatment of high-dose paracetamol-induced renal damage. </span> </p>}, number={30}