TY  - JOUR
T1  - Evaluation of the Effect of Thymol on the Cytotoxicity of Cetuximab in Lung Cancer Cells
TT  - Timol’ün Akciğer Kanseri Hücrelerinde Cetuximab'ın Sitotoksisitesi Üzerindeki Etkisinin Değerlendirilmesi
AU  - Erdoğan, Ayşe
AU  - Haznedar, Ekin
AU  - Başer, Mehmet
PY  - 2025
DA  - June
Y2  - 2025
DO  - 10.31594/commagene.1644311
JF  - Commagene Journal of Biology
JO  - Comm. J. Biol.
PB  - ABADER (Adıyaman Bilimsel Araştırmalar Derneği)
WT  - DergiPark
SN  - 2602-456X
SP  - 42
EP  - 48
VL  - 9
IS  - 1
LA  - en
AB  - The treatment of lung cancer continues to be a significant challenge for many oncologists and their patients. Treatment using epidermal growth factor receptor inhibitors is connected to a positive outcome. Cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor (EGFR), in conjunction with monoterpene phenol thymol, is recommended for the treatment of lung cancer. While a mild acne-like skin rash is quite frequent in patients using cetuximab, a severe rash is rare. The goal of the current study was to assess whether thymol could enhance the anticancer effectiveness of cetuximab in A-549, non-small cell lung cancer (NSCLC) cell line. We found that the combination of cetuximab and thymol synergistically suppressed cell proliferation by inducing membrane damaging, oxidative stress, and apoptosis in A-549 cells. Taken together, our results indicate that the combination of thymol and cetuximab could improve anticancer responses and may notably enhance treatment outcomes in NSCLC.
KW  - Cetuximab
KW  - carvacrol
KW  - lung cancer
KW  - synergistic anticancer effect
KW  - apoptosis
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UR  - https://doi.org/10.31594/commagene.1644311
L1  - https://dergipark.org.tr/en/download/article-file/4629492
ER  -