TY  - JOUR
T1  - The Value of Serum Cardiac Myosin Binding Protein C (cMyBP-C) Levels in Detecting Cardiac Contusion in an Experimental Blunt Thoracic Trauma Model
TT  - Deneysel Künt Toraks Travması Modelinde Kardiyak Kontüzyonun Saptanmasında Serum Kardiyak Miyozin Bağlayıcı Protein C (cMyBP-C) Düzeylerinin Değeri
AU  - Bayır, Aysegül
AU  - Kara, Hasan
AU  - Öztürk, Bahadir
AU  - Ünlükal, Nejat
AU  - Eseroğlu, Muhammed
AU  - Akkuş, Abdullah
AU  - Akbuğa, Fatih
AU  - İkiz, Fatih
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.47482/acmr.1647937
JF  - Archives of Current Medical Research
JO  - Arch Curr Med Res
PB  - 14 Mart Tıbbiyeliler Derneği
WT  - DergiPark
SN  - 2717-9788
SP  - 200
EP  - 208
VL  - 6
IS  - 3
LA  - en
AB  - Background: The aim of this study is to investigate the usability of Cardiac Myosin Binding Protein C (cMyBP-C) as a marker in demonstrating cardiac damage in the blunt thoracic trauma model.Methods: It was provided in the trauma groups bilateral blunt thoracic trauma (3.31 joules to the low-energy trauma group, 6.62 joules to the medium-energy trauma group, 9.93 jouls to the high-energy trauma group). Blood samples were taken 0th, 12th and 24th hours to examine cMyBP-C levels from the subjects. At the end of the experiment (24th hour), lung tissues were taken from the subjects for histopathological examination.Results: The mean cMyBP-C levels of the trauma groups at the 24th hour were statistically significantly higher than the control group (p=0.02). The mean cMyBP-C levels at the 24th hour of the low-energy trauma group, the 0th hour of the medium-energy trauma group, and the 12th and 24th hours of the high-energy trauma group were significantly higher than the control group (p=0.004, 0.007, 0.02, 0.03 respectively). A significant positive correlation was found in the bilateral correlation analysis between the contusion levels at 0th and 24th hours and cMyBP-C levels of the trauma groups (Spearman’s ρ= 0.396, p=0.04, spearman’s ρ= 0.473, p=0.01, respectively) . It was determined that the 24th hour cMyBP-C values (ng/ml)the sensitivity and specificity was 83.3% at the cut-off value of 11,150. Conclusion: cMyBP-C levels increase in cardiac contusion due to blunt thoracic trauma. However, more comprehensive experimental and clinical studies are required for the use of cMyBP-C as a biomarker in the diagnosis of cardiac contusion due to blunt thoracic trauma.
KW  - Cardiac Myosin Binding Protein C
KW  - myocardial injury
KW  - biomarkers
KW  - chest trauma
N2  - Giriş: Bu çalışmanın amacı, künt torasik travma modelinde kardiyak hasarı göstermede bir belirteç olarak Kardiyak Miyozin Bağlayıcı Protein C'nin kullanılabilirliğini araştırmaktır.Yöntemler: Travma gruplarına bilateral künt torasik travma sağlandı (düşük enerjili travma grubuna 3,31 joule, orta enerjili travma grubuna 6,62 joule, yüksek enerjili travma grubuna 9,93 joule). Deneklerden cMyBP-C seviyelerini incelemek için 0., 12. ve 24. saatlerde kan örnekleri alındı. Deneyin sonunda (24. saat), histopatolojik inceleme için deneklerden akciğer dokuları alındı.Sonuçlar: Travma gruplarının 24. saatteki ortalama cMyBP-C seviyeleri, kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksekti (p=0,02). Düşük enerjili travma grubunun 24. saatindeki, orta enerjili travma grubunun 0. saatindeki ve yüksek enerjili travma grubunun 12. ve 24. saatlerindeki ortalama cMyBP-C düzeyleri kontrol grubundan anlamlı derecede yüksekti (sırasıyla p=0,004, 0,007, 0,02, 0,03). İkili korelasyon analizinde 0. ve 24. saatlerdeki kontüzyon düzeyleri ile travma gruplarının cMyBP-C düzeyleri arasında anlamlı pozitif korelasyon bulundu (sırasıyla Spearman's ρ= 0,396, p=0,04, Spearman's ρ= 0,473, p=0,01). 24. saat cMyBP-C değerlerinin (ng/ml) duyarlılığının ve özgüllüğünün 11.150 kesme değerinde %83,3 olduğu belirlendi. Sonuç: cMyBP-C, künt torasik travmaya bağlı kardiyak hasarı ve derecesini değerlendirmede tanısal bir belirteç olarak kullanılabilir.
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UR  - https://doi.org/10.47482/acmr.1647937
L1  - https://dergipark.org.tr/en/download/article-file/4645856
ER  -