@article{article_1648658, title={RETROSPECTIVE REVIEW OF THE ROLE OF PREGABALIN IN PREOPERATIVE PAIN MANAGEMENT: MECHANISMS OF ACTION AND CLINICAL OUTCOMES}, journal={Acta Medica Nicomedia}, volume={8}, pages={282–286}, year={2025}, DOI={10.53446/actamednicomedia.1648658}, author={Kara, Yağmur and Eroglu, Füsun and Gökçe Ceylan, Berit}, keywords={Infraclavicular block, postoperative pain, preemptive analgesia, pregabalin}, abstract={Objective: Infraclavicular block is a commonly utilized technique in hand and forearm surgeries. Pregabalin, acknowledged for its efficacy in managing neuropathic and chronic pain, has emerged as a potential intervention for reducing postoperative pain when administered preoperatively. This study aimed to evaluate the impact of a single 150 mg dose of pregabalin, administered one hour prior to surgery, on block characteristics and postoperative analgesia requirement in patients undergoing hand and forearm surgery with infraclavicular block. Methods: The medical records of patients aged 18-65 years, classified as ASA I-II, who underwent hand and forearm surgeries under infraclavicular block, were retrospectively analyzed. All patients received regional antisepsis, a 30 ml volume (Bupivacaine+Lidocaine) was administered, and an ultrasound-guided infraclavicular block was performed. Patients were categorized into two groups: the pregabalin group (Group P), comprising 30 patients who received preemptive anesthesia with 150 mg pregabalin, and the control group (Group C), consisting of 30 patients who did not receive pregabalin. Hemodynamic parameters, postoperative pain intensity, time of initial pain onset, and time of first analgesic requirement were documented based on anesthesia records and patient follow-up forms. Results: Postoperative visual analog scale scores were lower in Group P at the 12th and 24th hours (p <0.05). The time to the first analgesic application was significantly longer in Group P compared to Group C. Conclusion: A single dose of 150 mg pregabalin administered one hour before surgery appears to reduce postoperative pain and analgesic requirements in patients undergoing surgery with peripheral regional block.}, number={3}, publisher={Kocaeli University}