TY  - JOUR
T1  - Quantification of Edoxaban Tosylate Monohydrate in Pharmaceutical API And Dosage Form by a Novel UV-Spectrophotmetric Method: Development and Validation
AU  - Dadi, Vasudha
AU  - Gandi, Anusha
AU  - Adari, Jagadeesh
AU  - Sappa, Manoj Kumar
AU  - Kollabathula, Varaprasada Rao
PY  - 2025
DA  - December
Y2  - 2025
DO  - 10.52794/hujpharm.1649224
JF  - Hacettepe University Journal of the Faculty of Pharmacy
JO  - HUJPHARM
PB  - Hacettepe University
WT  - DergiPark
SN  - 2458-8806
SP  - 329
EP  - 337
VL  - 45
IS  - 4
LA  - en
AB  - The major purpose of this analysis is to develop and validate easy, economic UV-spectrophotometric method useful in the quantification of Edoxaban tosylate monohydrate in active pharmaceutical ingredients (APIs). Standard and working solutions of Edoxaban tosylate monohydrate were prepared, followed by the preparation of aliquots of working solutions at various concentrations. The method was validated by assessing key parameters, including linearity, precision, accuracy, robustness, ruggedness, and the limits of detection and quantitation. The demonstrated method has excellent linearity for Edoxaban in the concentration range of 2-24 μg/mL, with a coefficient of determination (R²) was 0.9998. This method is suitable for routine analysis of Edoxaban in bulk form, offering a reliable tool for quality control in pharmaceutical settings.
KW  - Edoxaban
KW  - Method development
KW  - UV Spectrometry
KW  - Validation
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UR  - https://doi.org/10.52794/hujpharm.1649224
L1  - https://dergipark.org.tr/en/download/article-file/4651436
ER  -