@article{article_1649265, title={Antibacterial Activity of a Novel Phyto-Complex of Rhus Coriaria Extract on Growth of Early and Late Colonizer Cariogenic Bacteria}, journal={International Journal of Traditional and Complementary Medicine Research}, volume={6}, pages={94–101}, year={2025}, DOI={10.53811/ijtcmr.1649265}, author={Çelik, Zeynep Ceren and Tüzemen, Nazmiye Ülkü and Elbek Çubukçu, Çiğdem and Özakın, Cüneyt}, keywords={Dental caries, Rhus, Mouthwashes, Streptococcus mutans, Scardovia wiggsiae}, abstract={Aim: Rhus coriaria, commonly known as sumac, is a spice derived from the dried fruits of the Rhus genus supports oral health by potentially reducing bacterial growth and inflammation, making it a candidate for enhancing dental care products. The present study aimed to investigate the antimicrobial efficacy of a novel phyto-complex consisting a Rhus Coriaria extract, against early and late colonizers associated with cariogenic activity. Materials & Methods: Sonicated samples of experimental phyto-complex (G1-G5) contained aqueous extracts of Rhus coriaria at different concentrations of 0.0%; 6.25%; 12.5%; 18.75%; 25% and %5 propolis and adjunctive herbals. Antibacterial efficacy on Staphylococcus aureus, Escherichia coli, Streptococcus mitis, Streptococcus oralis, Streptococcus mutans and Scardovia wiggsiae was tested using the agar-well method. Results: All experimental groups containing Rhus coriaria extract (G2–G5) exhibited a concentration-dependent inhibition of growth for Staphylococcus aureus, Streptococcus mitis, Streptococcus oralis, Streptococcus mutans, and Scardovia wiggsiae, with the highest efficacy observed in G5 (25% extract). No inhibitory effects were observed against Escherichia coli across all formulations. Conclusion: A novel phyto-complex with the active ingredient Rhus Coriaria with antioxidant nature has demonstrated a concentration-dependent increasing inhibitory effect on Staphylococcus aureus and specific bacterial strains involved in the etiology of dental caries: Streptococcus mitis, Streptococcus oralis, Streptococcus mutans, and Scardovia wiggsiae.}, number={2}, publisher={Duzce University}