TY - JOUR T1 - Predictive Modeling of Diabetes Status Based on Vitamin D Levels and Clinical Parameters: A Machine Learning Investigation TT - Predictive Modeling of Diabetes Status Based on Vitamin D Levels and Clinical Parameters: A Machine Learning Investigation AU - Balcıoğlu, Yavuz Selim AU - Sertbakan, Kübra AU - Sezen, Bülent AU - Garip, Tayfun AU - Aslanbaş, Çağlayan PY - 2025 DA - November Y2 - 2025 DO - 10.34248/bsengineering.1649690 JF - Black Sea Journal of Engineering and Science JO - BSJ Eng. Sci. PB - Karyay Karadeniz Yayımcılık Ve Organizasyon Ticaret Limited Şirketi WT - DergiPark SN - 2619-8991 SP - 1985 EP - 1997 VL - 8 IS - 6 LA - en AB - Vitamin D deficiency has been associated with impaired glucose metabolism, but its predictive value for diabetes status remains incompletely characterized. We applied machine learning methodologies to investigate this relationship and develop predictive models based on vitamin D levels and clinical parameters. This cross-sectional study analyzed data from 817 patients with concurrent measurements of 25-hydroxyvitamin D and HbA1c. Patients were classified as having normal glucose metabolism (HbA1c KW - Vitamin D deficiency KW - Diabetes mellitus KW - HbA1c KW - Machine learning KW - Predictive modeling N2 - Vitamin D deficiency has been associated with impaired glucose metabolism, but its predictive value for diabetes status remains incompletely characterized. We applied machine learning methodologies to investigate this relationship and develop predictive models based on vitamin D levels and clinical parameters. This cross-sectional study analyzed data from 817 patients with concurrent measurements of 25-hydroxyvitamin D and HbA1c. Patients were classified as having normal glucose metabolism (HbA1c CR - Alvarez JA, Ashraf AP. 2009. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol, 2010: 351385. CR - Angellotti E, D’Alessio DA, Dawson-Hughes B, Nelson J, Cohen RM, Gastaldelli A, Pittas AG. 2018. Vitamin D supplementation in patients with type 2 diabetes: The vitamin D for established type 2 diabetes (DDM2) study. J Endocr Soc, 2(4): 310-321. CR - Argano C, Mirarchi L, Amodeo S, Orlando V, Torres A, Corrao S. 2023. The role of vitamin D and its molecular bases in insulin resistance, diabetes, metabolic syndrome, and cardiovascular disease: state of the art. Int J Mol Sci, 24(20): 15485. CR - Casey CF, Slawson DC, Neal LR. 2010. Vitamin D supplementation in infants, children, and adolescents. Am Fam Physician, 81(6): 745-748. CR - Hilbert K, Lueken U. 2020. Prädiktive analytik aus der perspektive der klinischen psychologie und psychotherapie. Verhaltenstherapie, 30(1): 8-17. CR - Karagöl A, Atak N. 2016. D vitamini ve Tip 2 diyabet. Türk Halk Sağlığı Derg, 14(3): 167-177. CR - Kartal Baykan E, Yıldırımer Y, Durmazatar İ. 2022. Tip 2 diyabetli bireylerde serum vitamin D düzeyleri ile mikroalbüminüri arasındaki ilişkinin değerlendirilmesi. Ege Tıp Derg, 61(1): 73-79. CR - Orhanoğlu T. 2024. Diyabetik hastalarda trombosit dağılım genişliği (PDW), ortalama trombosit hacmi (MPV) ve vitamin D düzeyi arasındaki ilişkinin incelenmesi. İst Gelişim Üniv Sağlık Bilim Derg, 24: 1081-1090. CR - Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. 2018. Complications of diabetes 2017. J Diabetes Res, 2018: 3086167. CR - Saadatmand K, Khan S, Hassan Q, Hautamaki RC, Ashouri R, Lua J, Doré S. 2021. Benefits of vitamin D supplementation to attenuate TBI secondary injury? Transl Neurosci, 12(1): 533-544. CR - Saeedi P, Petersohn I, Ke C, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R. 2019. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract, 157: 107843. CR - Tekin Karacaer N, Tuncer SÇ. 2022. Tip 2 diyabetik hastalarda glisemik kontrolün D vitamini, B12 vitamini ve lipid profili üzerini etkilerinin araştırılması: Bir retrospektif çalışma. Aksaray Üniv Tıp Bilim Derg, 3(3): 10-14. CR - Xu K, Li Y, Liu C, Liu X, Hao X, Gao J, Maropoulos P. 2020. Advanced data collection and analysis in data-driven manufacturing process. Chin J Mech Eng, 33(1): 43. UR - https://doi.org/10.34248/bsengineering.1649690 L1 - https://dergipark.org.tr/en/download/article-file/4653600 ER -