@article{article_1653716, title={Association of PTEN expression with hormone receptor status, tumor subtype, histological grade, and clinicopathological parameters in endometrial carcinomas}, journal={Pamukkale Medical Journal}, volume={18}, pages={530–539}, year={2025}, DOI={10.31362/patd.1653716}, author={Arman Karakaya, Yeliz and Koşar Can, Özlem}, keywords={Endometrial cancer, PTEN, tumor cells}, abstract={Purpose: This study investigates the relationship between PTEN expression and tumor characteristics and clinical outcomes in endometrial carcinoma (EC). EC is the most common malignancy of the female genital tract, typically classified into Type I (endometrioid, hormone-sensitive, favorable prognosis) and Type II (serous, aggressive, poor prognosis). PTEN is a tumor suppressor gene that regulates cell growth. Loss of PTEN expression is frequently observed in Type I EC and is associated with early tumorigenesis.
Materials and methods: A retrospective analysis was conducted on 186 EC cases. PTEN expression was evaluated immunohistochemically, and its association with tumor size, histological subtype, stage, hormone receptor status, and survival outcomes was analyzed.
Results: Loss of PTEN expression was detected in 81.2% of cases. While PTEN loss was more prevalent in tumors >3 cm in size, it did not show a significant correlation with stage, grading, myometrial invasion, or metastasis. p53 mutation and high-grade tumors were associated with poorer survival rates. Estrogen receptor (ER) and progesterone receptor (PR) expression were predominantly observed in endometrioid carcinoma.
Conclusions: Although PTEN loss is frequently observed in endometrioid EC, it does not directly impact survival outcomes. Hormone receptor status and genetic alterations play a crucial role in EC pathogenesis. Further studies on PTEN and other molecular markers may contribute to the development of personalized treatment strategies. These findings suggest that while PTEN loss plays a role in early tumor development, it is not a definitive prognostic factor in EC.}, number={3}, publisher={Pamukkale University}