TY - JOUR T1 - Association of Nerve Conduction Studies and Blood Parameters in Patients with Neuropathic Symptoms AU - Korucu, Osman AU - Ceren Akgör, Merve AU - Dağdeviren, Murat PY - 2025 DA - May Y2 - 2025 JF - Sanatorium Medical Journal JO - Sanatorium Med J PB - T.C. Sağlık Bakanlığı Ankara Atatürk Sanatoryum Eğitim ve Araştırma Hastanesi WT - DergiPark SN - 3062-3944 SP - 32 EP - 36 VL - 1 IS - 1 LA - en AB - Abstract Background: Diabetic neuropathy, particularly distal symmetric polyneuropathy, which is common complication of uncontrolled diyabetes mellitus (DM). Recent studies have linked impaired fasting glucose, OGTT results, HbA1c levels, and electromyography findings with neuropathy,but there is inconsistency in which parameters are most significant. The study aims to clarify the associations between metabolic parameters and neuropathy.Method: In this retrospective study, 1,000 neuropathic pain patients were reviewed, and 310 meeting the criteria were included. They were grouped as newly diagnosed or previously diagnosed with diabetes. The study aims to evaluate the relationship between insulin, insulin resistance, OGTT, fasting glucose, HbA1c, vitamin B12, and nerve conduction studies. Statistical analyses will be performed using SPSS 18.0, with a significance level of p ≤ 0.05.Results: The study included 310 patients (165 women, 145 men), with 255 diagnosed with polyneuropathy. Neuropathy was more common in diabetic patients (p=0.0001) and significantly associated with age (p=0.0001). No correlations were found with glucose metabolism parameters. Sensory and sensorimotor polyneuropathy were most common in non-diabetic patients.Conclusion: This study suggests aging accelerates nerve degeneration and vascular changes in polyneuropathy. No strong link was found between glucose metabolism and neuropathy, but insulin resistance remains relevant. Larger studies are needed to explore metabolic risk factors, especially prediabetes. Early diagnosis and management are crucial to prevent progressive neuropathy. KW - diabetes mellitus KW - diabetic neuropathy KW - electromyography CR - 1. Ziegler D, Papanas N, Vinik AI, et. al.Epidemiology of polyneuropathy in diabetes and prediabetes. Handb Clin Neurol. 2014;126:3-22. doi: 10.1016/B978-0-444-53480-4.00001-1. CR - 2. Kannan MA, Sarva S, Kandadai RM, et. al. Prevalence of neuropathy in patients with impaired glucose tolerance using various electrophysiological tests. Neurol India. 2014 Nov-Dec;62(6):656-61. doi: 10.4103/0028-3886.149393. 3. Gwathmey KG, Pearson KT. Diagnosis and management of sensory polyneuropathy. BMJ. 2019 May 8;365:l1108. doi: 10.1136/bmj.l1108. CR - 4. Gibbons CH, Freeman R. Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015 Jan;138(Pt 1):43-52. doi: 10.1093/brain/awu307. Epub 2014 Nov 11. CR - 5. Sahin M, Karatas M, Sahin M, et. al.High prevalence of neuropathy in patients with impaired 60-minute oral glucose tolerance test but normal fasting and 120-minute glucose levels. Minerva Endocrinol. 2008 Dec;33(4):289-96. CR - 6. Hoffman-Snyder C, Smith BE, Ross MA, et. al.Value of the oral glucose tolerance test in the evaluation of chronic idiopathic axonal polyneuropathy. Arch Neurol. 2006 Aug;63(8):1075-9. doi: 10.1001/archneur.63.8.noc50336. Epub 2006 Jun 12. CR - 7. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ; American Academy of Neurology; American Association of Electrodiagnostic Medicine; American Academy of Physical Medicine and Rehabilitation. Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2005 Jan 25;64(2):199-207. CR - 8. Vinik AI, Camacho P, Reddy S, et. al. AGING, DIABETES, AND FALLS. Endocr Pract. 2017 Sep;23(9):1117-1139. doi: 10.4158/EP171794.RA. Epub 2017 Jul 13. CR - 9. Hanewinckel R, van Oijen M, Ikram MA, et. al.The epidemiology and risk factors of chronic polyneuropathy. Eur J Epidemiol. 2016 Jan;31(1):5-20. doi: 10.1007/s10654-015-0094-6. Epub 2015 Dec 23. CR - 10. Ziegler D, Tesfaye S, Spallone V, et. al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022 Apr;186:109063. doi: 10.1016/j.diabres.2021.109063. Epub 2021 Sep 20. CR - 11. Hoffman-Snyder C, Smith BE, Ross MA, et. al. Value of the oral glucose tolerance test in the evaluation of chronic idiopathic axonal polyneuropathy. Arch Neurol. 2006 Aug;63(8):1075-9. doi: 10.1001/archneur.63.8.noc50336. Epub 2006 Jun 12. UR - https://dergipark.org.tr/en/pub/sanatoriummedj/issue//1656644 L1 - https://dergipark.org.tr/en/download/article-file/4685449 ER -