TY - JOUR T1 - The Role And Efficacy of High-Dose Steroid Therapy In COVID-19 Pneumonia: Insights From The Literature Along With An Original Research AU - Öztürk, Ayperi AU - Öztürk Ergür, Figen AU - Kavurgacı, Suna AU - Uzel Şener, Melahat AU - Yıldız, Murat PY - 2025 DA - May Y2 - 2025 JF - Sanatorium Medical Journal JO - Sanatorium Med J PB - T.C. Sağlık Bakanlığı Ankara Atatürk Sanatoryum Eğitim ve Araştırma Hastanesi WT - DergiPark SN - 3062-3944 SP - 17 EP - 24 VL - 1 IS - 1 LA - en AB - Introduction: Today, whereas hypoxemia and respiratory failure are the major challenging problems in the course of severe COVID-19 pneumonia, controlling the disease at a mild-moderate stage or stopping the inflammation by recognizing the cytokine storm early should be the most prominent goal. We aimed to reveal the clinical efficacy and safety of short-term high-dose corticosteroids in severe COVID-19.Material and Methods: This retrospective observational study consisted of 54 patients who were given high-dose steroids (HDS, >250 mg/day methylprednisolone, 3 days.). Low-dose steroid (LDS) therapy (dexamethasone 8 mg ) was applied to all patients. The HDS group was reviewed in terms of decreasing hospital mortality and preventing fibrosis development in follow-up.Results: During the observation period, out of 317 severe COVID-19 pneumonia hospitalized, HDS and LDS were administered to 54 and 216 patients, respectively. Higher body mass index, younger age, more oxygen need of patients at admission, and more need for advanced oxygen therapy during hospitalization were found in the HDS group (p KW - COVID-19 KW - high-dose steroid KW - methylprednisolone KW - mortality KW - fibrosis CR - 1. COVID-19 Map. [cited october 3, 2023]. 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