TY  - JOUR
T1  - Spanelastic as a vesicular nanocarrier for transdermal drug delivery system: Preparation, characterization and bioactive loading
AU  - Adulhussein, Yassir Mohamed
AU  - Rajab, Nawal Ayash
AU  - Kadhim, Enas Jawad
AU  - Abdulhamid, Shaimaa Nazar
AU  - Al-ani, Enas
PY  - 2025
DA  - April
Y2  - 2024
DO  - 10.12991/jrespharm.1666368
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 833
EP  - 840
VL  - 29
IS  - 2
LA  - en
AB  - Spanlastic is a novel surfactant-based elastic nanovesicle delivery system that has been shown to deliver many different types of drugs. The present review aimed to illustrate the structure, composition, evaluation and discuss some bioactive compounds that can be delivered by spanlastics. Spanlastics are composed of a non-ionic surfactant and an edge activator, which gives them their elasticity. This elasticity allows spanlastics to deform and squeeze through the skin pores, making them ideal for transdermal delivery. Spanlastics have also been shown to be effective in delivering drugs to the eye, buccal mucosa, and other tissues. Spanlastics have several advantages over other drug delivery systems. They are non-immunogenic, biodegradable, and chemically stable. They are also more elastic than liposomes, which makes them more effective at penetrating biological membranes. In addition, spanlastics can be formulated to target specific tissues, which can improve the therapeutic efficacy of the drug. Spanlastics are a promising new drug delivery system with a wide range of potential applications. They are currently being investigated for the treatment of a wide range of diseases, including cancer, inflammation, and infectious diseases. Finally, this review leads to a conclude that Spanelastic can be used as a good Vesicular Nanocarrier for transdermal drug delivery system.
KW  - Spanelastic
KW  - vesicular nanocarrier
KW  - transdermal drug delivery
KW  - olive tree
KW  - curcumin
KW  - green tea
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UR  - https://doi.org/10.12991/jrespharm.1666368
L1  - https://dergipark.org.tr/en/download/article-file/4729011
ER  -