TY - JOUR T1 - Evaluation of Antioxidant, Antiproliferative and Anticholinesterase Activities of Iberis carnosa Willd AU - Uysal, İmran PY - 2025 DA - June Y2 - 2025 DO - 10.32571/ijct.1668024 JF - International Journal of Chemistry and Technology JO - Int. J. Chem. Technol. PB - Rabia ACEMİOĞLU WT - DergiPark SN - 2602-277X SP - 91 EP - 96 VL - 9 IS - 1 LA - en AB - This study investigated the bioactivity of Iberis carnosa Willd, a plant known for its diverse natural compound. Utilizing Soxhlet extraction, an ethanol extract was prepared and subsequently analyzed for antioxidant, antiproliferative, and anticholinesterase activities. Antioxidant capacity was quantified using Rel Assay kits, yielding a total antioxidant status (TAS) of 4.489±0.095 mmol/L, a total oxidant status (TOS) of 11.325±0.130 µmol/L, and an oxidative stress index (OSI) of 0.252±0.003. Antiproliferative activity was assessed against the A549 lung cancer cell line, demonstrating a dose-dependent inhibition of cell growth. Anticholinesterase activity was evaluated by measuring acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition, revealing values of 76.52±1.93 μg/mL for AChE and 119.84±1.50 μg/mL for BChE, respectively. These findings suggest that I. carnosa possesses significant biological activities and warrants further investigation for potential therapeutic applications, particularly in neurodegenerative diseases and cancer. KW - Iberis carnosa KW - antioxidant activity KW - antiproliferative effect KW - anticholinesterase activity KW - A549 cell line KW - biological activity CR - 1. Sevindik, M.; Yazar, M.; Polat, A. O.; Karatepe, H. K.; Uysal, İ.; Özdemir, B.; Uysal, N. Indian Journal of Natural Products and Resources, 2024,15, 473-490. CR - 2. Abdel-Aziz, S. M.; Aeron, A.; Kahil, T. A. Microbes in food and health, 2016, 97-116. CR - 3. 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UR - https://doi.org/10.32571/ijct.1668024 L1 - https://dergipark.org.tr/en/download/article-file/4736700 ER -