TY  - JOUR
T1  - Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma
AU  - Nenni, Merve
AU  - Tehçi, Tuğba
PY  - 2025
DA  - December
Y2  - 2025
DO  - 10.52794/hujpharm.1669708
JF  - Hacettepe University Journal of the Faculty of Pharmacy
JO  - HUJPHARM
PB  - Hacettepe University
WT  - DergiPark
SN  - 2458-8806
SP  - 338
EP  - 344
VL  - 45
IS  - 4
LA  - en
AB  - Melasma, a condition causing uneven brown patches on the forehead, cheeks, and chin, is classified into epidermal, dermal, mixed, and indeterminate types. Treatment options include tranexamic acid (TXAA), which has been increasingly used recently. The 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a widely accepted and often employed test for quantifying the overall antioxidant capacity of substances. The DPPH method was used to calculate the antioxidant scavenging percentages of TXAA and ascorbic acid (vitamin C). TXAA showed a DPPH radical scavenging activity of 60.77±0.34% at 50,000 ppm, while ascorbic acid showed a DPPH radical scavenging activity of 95.77±0.59% at 1000 ppm. Ascorbic acid is a known powerful antioxidant. After examining the results, it is clear that TXAA exhibits antioxidant activity, although it is less potent than the antioxidant effect of ascorbic acid.
KW  - Tranexamic acid
KW  - DPPH
KW  - Antioxidant
KW  - Ascorbic acid
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UR  - https://doi.org/10.52794/hujpharm.1669708
L1  - https://dergipark.org.tr/en/download/article-file/4743956
ER  -