TY  - JOUR
T1  - Evaluation of Thyroid Functions After Radiotherapy in Primary Head and Neck Malignancies without Surgery
TT  - Ameliyatsız Primer Baş ve Boyun Malignitelerinde Radyoterapi Sonrası Tiroid Fonksiyonlarının Değerlendirilmesi
AU  - Apsar Başaran, Özlem
AU  - Elmas, Özlem
AU  - Kozan, Ramazan
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.29058/mjwbs.1671819
JF  - Medical Journal of Western Black Sea
JO  - Med J West Black Sea
PB  - Zonguldak Bulent Ecevit University
WT  - DergiPark
SN  - 2822-4302
SP  - 231
EP  - 238
VL  - 9
IS  - 2
LA  - en
AB  - Aim: In this study, it was aimed to investigate thyroid dysfunction in patients who underwent radiotherapy due to primary head and neckmalignancy.Material and Methods: The study was carried out between January 1, 2008 and January 31, 2017 at Zonguldak Bulent Ecevit UniversityHealth Practice and Research Hospital with patients who received radiotherapy due to primary malignancy of the head and neck region anddid not undergo surgery. The data were recorded retrospectively from hospital records. All analyses were performed on SPSS v21 (SPSSInc., Chicago, IL, USA). Two-tailed p-values of less than 0.05 were considered statistically significant. Results: The results of a total of 132 cancer patients were examined. Cancers examined mostly consisted of 52.28% (n = 69) glottic /supraglottic larynx cancer, 15.15% (n = 20) nasopharynx cancer, and 6.06% (n = 8) hodgkin lymphoma patients. In addition to ;78.8% (n= 104) of the patients were male and the median age was 60.5 (min = 15, max = 84) years. Median duration of treatment was 44 (min = 8,max = 354) days. It was determined that 28.8% (n = 38) of the patients had abnormal TSH value. Hypothyroidism developed in 15.9% (n =21) of the individuals and hyperthyroidism developed in 12.9% (n = 17). And 29.0% (n = 11) of the TSH abnormalities determined in the preradiotherapyperiod and 71.0% in the post-radiotherapy period. There was no significant difference in age and gender between the normalTSH group and those that had abnormal TSH after radiotherapy; however, the age of patients with abnormal TSH value before radiotherapywas significantly higher (p
KW  - Head and neck malignancies
KW  - Radiotherapy
KW  - Thyroid dysfunction
N2  - Amaç: Bu çalışmada primer baş ve boyun malignitesi nedeniyle radyoterapi uygulanan hastalarda tiroid fonksiyon bozukluğunun araştırılmasıamaçlandı.Gereç ve Yöntemler: Çalışma 1 Ocak 2008 ile 31 Ocak 2017 tarihleri arasında Zonguldak Bülent Ecevit Üniversitesi Tıp FakültesiHastanesi'nde baş ve boyun bölgesinin primer malignitesi nedeniyle radyoterapi alan ve ameliyat geçirmeyen hastalarla gerçekleştirildi.Veriler retrospektif olarak hastane kayıtlarından kaydedildi.Bulgular: Toplam 132 kanser hastasının sonuçları incelendi. İncelenen bireylerin %52.28 (n = 69) glottik / supraglottik larinks kanseri,%15.15 (n = 20) nazofarenks kanseri ve %6.06 (n = 8) hodgkin lenfoma hastalarından oluşuyordu. Hastaların %78.8'i (n = 104) erkekti veortanca yaş 60.5 idi. Medyan tedavi süresi 44 (min = 8, maks = 354) gündü. Hastaların %28.8'inde (n = 38) anormal TSH değeri saptandı.Bireylerin %15.9'unda (n = 21) hipotiroidizm, %12.9'unda (n = 17) hipertiroidizm gelişti. Radyoterapi öncesi dönemde TSH anormalliği%29.0'ında (n = 11) ve radyoterapi sonrası dönemde %71.0'ında tespit edildi. Normal TSH grubu ile radyoterapi sonrası anormal TSH'siolanlar arasında yaş ve cinsiyet açısından anlamlı fark yoktu; ancak radyoterapi öncesi anormal TSH değeri olan hastaların yaşı anlamlıolarak daha yüksekti (p
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UR  - https://doi.org/10.29058/mjwbs.1671819
L1  - https://dergipark.org.tr/en/download/article-file/4753701
ER  -