@article{article_1674768, title={Contemporary Implications of Incidental Prostate Cancer in Radical Cystoprostatectomy}, journal={Konuralp Medical Journal}, volume={17}, pages={267–272}, year={2025}, DOI={10.18521/ktd.1674768}, author={Özgür, Günal and Şenoğlu, Yusuf and Akay, Halil Batur and Kars, Murat and Toper, Hasan and Tınay, İlker and Çam, Haydar Kamil}, keywords={Bladder Cancer, Prostate Cancer, Radical Cystectomy, Cystoprostatectomy}, abstract={Objective: The aim of this study was to document the incidence, histopathologic characteristics, and clinical features of incidental prostate cancer (IPC) in a series of radical cystoprostatectomies (RCP). Method: The clinical and histopathological features of 96 male patients who underwent RCP between 2018 and 2024 were retrospectively evaluated. Results: IPC was detected in 30 (31.25%) of the patients. The majority of patients with IPC had a Gleason Score of 6 (76.67%) and organ-confined pT1-pT2 disease (90%). On the other hand, 6 (6/30, 20%) of the patients with ICP had clinically significant prostate cancer (PC) (Gleason > 3+4). Preoperative PSA values were higher in IPC patients (3.27 [1.16-5.8] ng/dL vs. 1.24 [0.79-2.36] ng/dL) (p=0.01). Survival was lower in patients with pT3-pT4 disease [13 (26.5%) vs. 25 (53.2%)], positive lymph nodes [7 (14.3%) vs. 16 (34%)], and lymphovascular invasion [12 (24.5%) vs. 29 (61.7%)] (p=0.015, 0.023, and 0.001, respectively) in the pathology of bladder cancer (BC). No difference in overall survival rates was found between patients with and without IPC [16 (32.7%) vs. 14 (29.8%)] (p=0.762). Conclusions: A higher preoperative PSA level could predict the presence of IPC in RCP patients. Approximately 20% of the PC patients had clinically significant PC, which requires PSA monitoring. However, overall survival is primarily related to BC.}, number={3}, publisher={Duzce University}, organization={This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors}