TY  - JOUR
T1  - Prognostic Significance of Histopathological and Hematological Markers in Gastrointestinal Stromal Tumors
TT  - Gastrointestinal Stromal Tümörlerde Histopatolojik ve Hematolojik Belirteçlerin Prognostik Rolü
AU  - Cantürk, Alp Ömer
AU  - Şentürk, Adem
AU  - Gönüllü, Emre
AU  - Harmantepe, Ahmet Tarık
AU  - Capoglu, Recayi
AU  - Mutlu, Fuldem
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.53446/actamednicomedia.1677338
JF  - Acta Medica Nicomedia
JO  - Acta Med Nicomedia
PB  - Kocaeli University
WT  - DergiPark
SN  - 2717-8994
SP  - 287
EP  - 294
VL  - 8
IS  - 3
LA  - en
AB  - AbstractObjective: This study aimed to evaluate the relationship between overall survival and preoperative systemic inflammation and nutritional indices in patients with gastrointestinal stromal tumors (GIST), in addition to conventional histopathological parameters.Methods: In this retrospective study, 43 patients who underwent surgery for GIST were analyzed. Demographic, laboratory, and pathological data were reviewed. Inflammatory and nutritional indices—including HALP, NLR, SII, PNI, and CRP/Albumin—were calculated from preoperative blood parameters. Their effects on 3-year survival were assessed using the Kaplan-Meier method and the log-rank test.Results: High mitotic count and Ki67 index were significantly associated with decreased survival. Patients with elevated RDW levels had significantly shorter survival times (p
KW  - GIST
KW  - systemic inflammation
KW  - survival
KW  - HALP
KW  - NLR
KW  - PNI
KW  - SII
KW  - CRP/Albumin
KW  - RDW
N2  - Giriş: Bu çalışmada, gastrointestinal stromal tümör (GIST) tanısı almış ve cerrahi tedavi uygulanmış hastalarda, klasik histopatolojik parametrelerin yanı sıra preoperatif dönemde elde edilen sistemik inflamasyon ve beslenme indekslerinin sağkalım ile ilişkisi değerlendirildi.Gereç ve Yöntem:Retrospektif olarak tasarlanan bu çalışmaya, GIST tanısı ile cerrahi uygulanmış 43 hasta dahil edildi. Hastaların demografik, laboratuvar ve patolojik verileri incelendi. Hematolojik parametrelerden hesaplanan HALP, NLR, SII, PNI ve CRP/Alb gibi indekslerin 3 yıllık sağkalım üzerindeki etkileri Kaplan-Meier yöntemi ve log-rank testi ile değerlendirildi.Bulgular:Yüksek mitoz sayısı ve Ki67 proliferasyon indeksi, sağkalımı olumsuz etkileyen anlamlı histopatolojik faktörler olarak belirlendi. RDW düzeyi yüksek olan hastalarda sağkalım süresi anlamlı şekilde daha kısaydı (p
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UR  - https://doi.org/10.53446/actamednicomedia.1677338
L1  - https://dergipark.org.tr/en/download/article-file/4778709
ER  -