TY  - JOUR
T1  - Wound healing activities of eucalyptol on full thickness excisional skin wound model in rats
AU  - Deveci, Mehmet Zeki Yılmaz
AU  - Kırgız, Ömer
AU  - Özkan, Hüseyin
AU  - İşler, Cafer Tayer
AU  - Kazak Akçakavak, Filiz
AU  - Yurtal, Ziya
AU  - Yakan, Akın
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.33988/auvfd.1677537
JF  - Ankara Üniversitesi Veteriner Fakültesi Dergisi
JO  - Ankara Univ Vet Fak Derg
PB  - Ankara University
WT  - DergiPark
SN  - 1300-0861
SP  - 1
EP  - 10
LA  - en
AB  - A plant-derived monoterpene, eucalyptol (1,8-cineole), has been suggested to have antioxidant, anti-inflammatory, and antimicrobial properties. The wound-healing effects of eucalyptol remain unknown. This study aimed to evaluate the topical use of eucalyptol at two concentrations on a full-thickness excisional skin wound model in terms of wound healing, gene expression, biochemical changes, and histopathological changes. Sixty Wistar rats were randomly divided into 5 groups (n = 12 per group). The control group (C) was untreated. Full-thickness excisional skin wounds were created in the following groups: the vehicle group (V), which was treated with polysorbate 80 solution (negative control). The Dexpanthenol group (D) was treated with dexpanthenol ointment (positive control). Eucalyptol 5% (E5) and Eucalyptol 10% (E10) groups were treated with 5% and 10% eucalyptol, respectively. Wound areas were measured on days 1, 4, 7, 11, 14, 18, and 21 days after wound creation. Wound tissues were collected on days 7 and 21. Histopathological, gene expression (TNFα, IL10, TGFβ1, VEGF), and biochemical (MDA, rGSH, GPx, CAT) analyses were performed on the wound tissues. TNFα gene expression levels were upregulated in Groups V and E5 (P
KW  - cineole
KW  - cutaneous
KW  - dermatology
KW  - experimental
KW  - topical
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UR  - https://doi.org/10.33988/auvfd.1677537
L1  - https://dergipark.org.tr/en/download/article-file/4779534
ER  -