TY  - JOUR
T1  - Alzheimer's Disease: A New Paradigm, New Treatments, New Challenges, New Approaches
AU  - Hanoğlu, Lütfü
AU  - Eruçar, Deniz
AU  - Aliyeva, Tehran
AU  - Tağraf, Beyza
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.52675/jhesp.1680912
JF  - Journal of  Health Systems and Policies
JO  - JHESP
PB  - Istanbul Medipol University
WT  - DergiPark
SN  - 2667-4920
SP  - 59
EP  - 76
VL  - 7
IS  - 1
LA  - en
AB  - Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. Recent advances in biomarker-based diagnostics and disease-modifying therapies have shifted the landscape of AD from symptom management to early intervention. This review examines current therapeutic innovations, with a particular focus on monoclonal antibodies such as lecanemab, aducanumab, and donanemab. While these agents show potential in slowing disease progression by targeting amyloid-beta accumulation, concerns remain regarding their clinical efficacy, safety profiles, and cost-effectiveness—especially in aging populations with high healthcare burdens. Additionally, developments in biological diagnosis through fluid and imaging biomarkers have introduced new ethical and policy-related challenges. The paper also highlights the role of non-pharmacological interventions, such as multidomain lifestyle programs, in enhancing cognitive reserve and delaying disease onset. Finally, the article calls for a comprehensive public health approach that includes precision medicine, national screening strategies, and policy reforms to address the growing societal impact of Alzheimer’s disease.
KW  - Alzheimer’s disease
KW  - monoclonal antibodies
KW  - biomarkers
KW  - cognitive reserve
KW  - public health
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UR  - https://doi.org/10.52675/jhesp.1680912
L1  - https://dergipark.org.tr/en/download/article-file/4793760
ER  -