TY  - JOUR
T1  - Prognostic Significance of Mismatch Repair Protein Expression and Its Association with Clinical Outcomes in Endometrial Cancer
TT  - Endometrial Kanserde Mismatch Repair Protein Ekspresyonunun Prognostik Önemi ve Klinik Sonuçlarla İlişkisi
AU  - Yüceer, Ramazan Oğuz
AU  - Kıran, Mehmet
AU  - İscan, Serhan Can
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.22312/sdusbed.1681755
JF  - Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi
PB  - Süleyman Demirel University
WT  - DergiPark
SN  - 2146-247X
SP  - 203
EP  - 211
VL  - 16
IS  - 2
LA  - en
AB  - Objective: This study aimed to evaluate the expression of mismatch repair (MMR) proteins in patients with endometrial cancer (EC), compare the findings with clinicopathological data, and investigate their prognostic implications. Materials and Methods: A total of 116 patients diagnosed with EC via endometrial biopsy or resection at Isparta City Hospital between March 1, 2017, and January 1, 2023, were included. Immunohistochemical analysis was performed to assess the expression of MMR proteins (MLH1, PMS2, MSH2, MSH6). Patients were classified as microsatellite stable (MSS) or microsatellite instable (MSI) based on MMR protein expression, and correlations with clinicopathological features and survival outcomes were analyzed. Results: Among the patients, 83.6% were classified as MSS and 16.4% as MSI. MSI was more frequently observed in patients under 60 years of age, with endometrioid type, low tumor grade, and hormone receptor positivity; however, these associations were not statistically significant. Estrogen receptor (ER) positivity, p53 mutation status, and microsatellite instability (MSI) were significant predictors of survival in endometrial cancer. The median overall survival (OS) was 31 months in the MSS group and 52 months in the MSI group, indicating a statistically significant difference (p = 0.002). Conclusion: MMR deficiency and MSI status are of prognostic significance in EC. MSI positivity is associated with longer survival and increased sensitivity to immunotherapy, highlighting its value as a clinically meaningful biomarker. Molecular classification can provide guidance for personalized treatment strategies.
KW  - Endometrial cancer
KW  - Mismatch Repair Protein
KW  - Instability
KW  - Survival
N2  - Amaç: Bu çalışmada, endometrial kanser (EK) hastalarında MMR (Mismatch Repair) protein ekspresyonunu değerlendirmek, bu bulguları klinikopatolojik verilerle karşılaştırmak ve prognostik etkilerini incelemek amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, 1 Mart 2017 - 1 Ocak 2023 tarihleri arasında Isparta Şehir Hastanesi’nde endometrial biyopsi veya rezeksiyon ile EK tanısı alan 116 hasta dahil edilmiştir. MMR protein ekspresyonu (MLH1, PMS2, MSH2, MSH6) immünohistokimyasal yöntemle değerlendirilmiştir. MSS (mikrosatellit stabil) ve MSI (mikrosatellit instabil) olarak sınıflandırılan hastalar klinikopatolojik özellikler ve sağkalım açısından analiz edilmiştir. Bulgular: Hastaların %83.6’sı MSS, %16.4’ü MSI olarak saptanmıştır. MSI olguları daha çok
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UR  - https://doi.org/10.22312/sdusbed.1681755
L1  - https://dergipark.org.tr/en/download/article-file/4797515
ER  -