TY  - JOUR
T1  - The Effects of Ferula elaeochytris on the Oxidant/Nitrosative Stress in Experimental Myoglobinuric Acute Renal Failure
AU  - Güngör, Meltem
AU  - Yalın, Serap
AU  - Ballı, Ebru
AU  - Bayrak, Gulsen
AU  - Yıldız, Fatma
AU  - Yıldırım, Metin
AU  - Pavlopoulou, Athanasia
AU  - Georgakılas, Alexandros G
AU  - Temel, Gülhan
AU  - Yalın, Ali Erdinç
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.52794/hujpharm.1683794
JF  - Hacettepe University Journal of the Faculty of Pharmacy
JO  - HUJPHARM
PB  - Hacettepe University
WT  - DergiPark
SN  - 2458-8806
SP  - 231
EP  - 244
VL  - 45
IS  - 3
LA  - en
AB  - Free radicals and nitric oxide play an important role in the pathogenesis of Myoglobinuric Acute Renal Failure (mARF). Herein, we aimed to investigate the effects of Ferula elaeochytris on the oxidative-antioxidant system and nitrosative stress in experimental mARF. In our study, 56 Sprague-Dawley rats, equally divided in seven groups, were used as model organisms of experimentally induced mARF. A disease model of mARF was established with 50% glycerol in all groups except one. Moreover, 40 mg/kg and 80 mg/kg of F. elaeochytris root extract were administered intragastrically before and after model creation. The following were investgated in the kidney tissue: serum urea nitrogen, urea, creatinine, sodium and potassium levels of rats in all groups; urinary urea and creatinine levels; MDA, SOD, GPx, CAT, NO and nitrotyrosine parameters. In addition, histological changes in the kidney were recorder with electron microscopy. Significant changes were observed in the CAT, GPx and MDA values of all groups compared to the control group. Electron microscopy observations also supported these findings. Herein, we provide evidence regarding the limited protective and curative effects of Ferula elaeochytris on mARF through reduction of the oxidant/nitrosative stress.
KW  - Ferula elaeochytris
KW  - myoglobinuric acute renal failure
KW  - nitrosative stress
KW  - oxidative stress.
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UR  - https://doi.org/10.52794/hujpharm.1683794
L1  - https://dergipark.org.tr/en/download/article-file/4806454
ER  -