TY  - JOUR
T1  - LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)
AU  - Gözcü, Sefa
AU  - Akşit, Zeynep
AU  - Şimşek, Samed
AU  - Kandemir, Ali
AU  - Aydın, Ali
AU  - Yılmaz, Mustafa Abdullah
AU  - Akşit, Hüseyin
PY  - 2025
DA  - July
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 961
EP  - 973
VL  - 28
IS  - 4
LA  - en
AB  - The study aimed to comprehensively identify the phenolic fingerprint of Morina persica L. (Caprifoliaceae) and evaluate its various biological activities. LC-MS/MS analysis of 70% Morina persica methanol extract revealed the presence of 27 phytochemicals, with quinic acid, chlorogenic acid, and rutin being the major phenolics. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities were evaluated for biological screening. The results showed that the methanolic extract of M. persica has a moderate DPPH radical scavenging and ferric-reducing capacity, indicating antioxidant activity. M. persica was observed to have a sufficient antiproliferative effect against cancer cells and low cytotoxicity against normal cells. Moreover, M. persica demonstrated good antibacterial activity against Clostridium perfringens, Enterococcus faecalis, and Escherichia coli. These data suggest that the methanolic extract of M. persica could be considered both an industrial source of quinic acid and a potential biologically active ingredient for developing drug formulations.
KW  - Morina persica L.
KW  - antibacterial
KW  - antioxidant
KW  - antiproliferative
KW  - LC-MS/MS
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