@article{article_1687706, title={In vitro Evaluation of Antibacterial Activity 2-benzoxazolinone and Its Combination Interaction with Ciprofloxacin}, journal={EMU Journal of Pharmaceutical Sciences}, volume={8}, pages={14–19}, year={2025}, DOI={10.54994/emujpharmsci.1687706}, author={Özbil, Ertuğrul}, keywords={2-benzoxazolinone, Antibacterial, Checkerboard, Ciprofloxacin.}, abstract={In the present study, it was aimed to demonstrate the antibacterial and synergistic activities of 2-benzoxazolinone, a promising allelochemical, against Klebsiella pneumoniae ATCC 700603, Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, and Staphylococcus aureus ATCC 25923 via broth microdilution method. 2-benzoxazolinone exhibited promising antibacterial activity against all tested bacteria with 4 mg/mL against E. coli and E. faecalis, and K. pneumoniae and S. aureus 2 mg/mL against. When used in combination with ciprofloxacin, no antagonistic activity was observed. However, the combination interaction revealed indifferent activity against all tested strains. Overall, the antibacterial data obtained from the study demonstrated that 2-benzoxazolinone can further be used as a potential antibacterial agent in the treatment of bacterial infections.}, number={1}, publisher={Dogu Akdeniz University}