TY  - JOUR
T1  - INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT
AU  - Kiziltunc, Husnu Serdar
AU  - Tekin, Salim Başol
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.55895/sshs.1688217
JF  - Sabuncuoglu Serefeddin Health Sciences
JO  - SSHS
PB  - Amasya University
WT  - DergiPark
SN  - 2667-6338
SP  - 17
EP  - 21
VL  - 7
IS  - 1
LA  - en
AB  - Gastric cancers continues to be one of the most important health problems in our society with high morbidity and mortality rates.  Based on genomic characterization, gastric cancer has recently been defined as a heterogeneous disease consisting of different subtypes, each with unique molecular features and specific clinics. In this study, we tried to investigate the frequency of microsatellite instability in gastric cancers and its effects on the disease. In our study, microsatellite instability results of the patients were seen as microsatellite stable (MSS) in 45 (90%) patients, microsatellite instability high (MSI-H) in 2 (4%) patients and microsatellite instability low (MSI-L) in 3 (6%) patients. It was observed that microsatellite stability was an independent risk factor for mortality. (p=0.035). As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.
KW  - Gastric cancer
KW  - Microsatellite instability
KW  - Morbidity
KW  - Mortality
KW  - Treatment
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UR  - https://doi.org/10.55895/sshs.1688217
L1  - https://dergipark.org.tr/en/download/article-file/4824291
ER  -