TY - JOUR T1 - Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss. AU - Kürkçüoğlu, Mine AU - Ağalar, Hale Gamze AU - Temiz, Burak AU - Duran, Ahmet AU - Paksoy, Mehmet Yavuz AU - Başer, Kemal Hüsnü Can PY - 2025 DA - June JF - Journal of Research in Pharmacy JO - J. Res. Pharm. PB - Marmara University WT - DergiPark SN - 2630-6344 SP - 790 EP - 798 VL - 26 IS - 4 LA - en AB - This study was aimed to evaluate the potential uses of Ferulago longistylis Boiss. essential oils in cosmetic applications. The air dried roots and fruits were subjected to water distillation by using a Clevenger apparatus for 3 h. Both essential oils were analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS) systems, simultaneously. The essential oil yields of the fruits and roots were calculated as 4% and 0.91%, respectively. The major compounds were identified as 2,3,6-trimethylbenzaldehyde (29.5%), cis-chrysanthenyl acetate (15.2%), (Z)-β-ocimene (12.4%), α-pinene (12.0%) and myrcene (11.4%) in the fruit essential oil while the root essential oil was characterized with high content of α-pinene (90.5%). Both essential oils were evaluated for their potential antioxidant and antityrosinase activities. The both essential oils showed weak Trolox equivalent antioxidant capacity and DPPH radical scavenging activity. The fruit essential oil showed weak antityrosinase (%25 inhibition, 1 mg/mL) activity while the root essential oil was inactive. The results concluded that both essential oils were not promising in cosmetic applications. KW - Ferulago longistylis KW - α-pinene; 2 KW - 3 KW - 6-trimethylbenzaldehyde KW - antioxidant KW - antityrosinase CR - [1] Gonzalez-Minero FJ, Bravo-Diaz L. The use of plants in skin-care products, cosmetics and fragrances: Past and present. Cosmetics. 2018; 5(3): 50. 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