TY  - JOUR
T1  - Preliminary research on ibuprofen self-emulsifying formulation
AU  - Yahaya, Zwanden Sule
AU  - Kurfi, Fatima Shuaibu
AU  - Mallam, Danjuma
AU  - Oloyede, Rukayyat Bukola
AU  - Adeleye, Olutayo Ademola
AU  - Okpanachi, Gideon Owoicho
PY  - 2025
DA  - June
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 834
EP  - 841
VL  - 26
IS  - 4
LA  - en
AB  - Ibuprofen is an important and commonly used nonsteroidal anti-inflammatory medication (NSAID). Its medicinal potentials are however severely hindered due to its poor water solubility and low oral absorption. A self-nano emulsifying drug delivery system (SNEDDS) is a lipid formulation that takes advantage of the solubilizing capacity of a mixture of oil, surfactant, and cosurfactant to improve intestinal permeability. The aim of this study is to develop SNEDDS of ibuprofen employing both labrafac CC and a natural lipophile (N-L) (vegetable oil) from pressed sesame seeds to improve the anti-inflammatory activity of ibuprofen. The formulation was stable against phase separation and drug precipitation, exhibited rapid emulsification within 5 s to yield an emulsion with a mean droplet size of 27.23 nm and showed a significant (p = 0.000) increase in anti-inflammatory properties compare to the aqueous suspension of the standard drug and each treatment agent across the test period. Overall, SNEDDS of ibuprofen with desirable physicochemical properties and improved anti-inflammatory activities were successfully developed using an un-refined lipophile obtained from pressed sesame seed.
KW  - Self-emulsification
KW  - nano
KW  - bioavailability
KW  - ibuprofen
KW  - anti-inflammatory
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UR  - https://dergipark.org.tr/en/pub/jrespharm/issue//1688880
L1  - https://dergipark.org.tr/en/download/article-file/4826835
ER  -