TY - JOUR T1 - Orodispersible tablets of telmisartan through cyclodextrin-surfactant complexation: A quality by design approach AU - Potti, Lakshmanarao AU - Avula, Prameela Rani PY - 2025 DA - June JF - Journal of Research in Pharmacy JO - J. Res. Pharm. PB - Marmara University WT - DergiPark SN - 2630-6344 SP - 1202 EP - 1213 VL - 26 IS - 5 LA - en AB - Telmisartan is a poorly water-soluble drug with dissolution limited bioavailability. In this work,solubility and dissolution rate were aimed to improve through the development of cyclodextrin (CD)complexes containing surfactant; followed by developing them into orodispersible tablets (ODTs). Qualityby design approach was adopted in the optimization of CD-surfactant complex as well as in the optimizationof ODTs. Type of cyclodextrins, the concentration of the cyclodextrins, and concentration of poloxamer 188were taken as the factors in the preparation of inclusion complexes by solvent evaporation method.Solubility was taken as the response variable. The optimized formulation of the complex was taken for ODTspreparation. Concentration of povidone, concentration of super-disintegrant and type of super-disintegrantwere taken as the independent factors, and disintegration time (DT) and time for 90% dissolution (T90%)were taken as the responses. The tablets were prepared by direct compression technique. The results of boththe responses were analyzed by response surface quadratic model for the influence of the factors on them.All three factors were found to have significant influence on both the responses (at p < 0.05). Graphicaloptimization was performed by desirability functions approach in order to have low DT and low T90%. Theoptimized telmisartan CD-surfactant complex was found to have a solubility of 2.86 mg/mL. The optimizedODTs were found to have 20.4 sec. DT and 7.3 min. T90%. These results indicated that enhancement ofsolubility of telmisartan as well as dissolution of the ODTs was successfully improved through quality bydesign approach. KW - Quality by design KW - solubility enhancement KW - dissolution enhancement KW - inclusion complexes KW - optimization KW - telmisartan KW - orodispersible tablets CR - [1] Bhowmik D, Bhanot R, Gautam D, Rai P, Kumar KP. Formulation and evaluation of telmisartan fast dissolving tablets by direct compression method. Res J Pharm Dosage Form Tech. 2017; 9(3): 131-139. [CrossRef] CR - [2] Park J, Cho W, Cha KH, Ahn J, Han K, Hwang SJ. Solubilization of the poorly water-soluble drug, telmisartan, using supercritical anti-solvent (SAS) process. Int J Pharm. 2013 Jan 30;441(1-2):50-55. [CrossRef] CR - [3] Diana R, Jafari M. 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[CrossRef] UR - https://dergipark.org.tr/en/pub/jrespharm/issue//1690855 L1 - https://dergipark.org.tr/en/download/article-file/4834558 ER -