TY - JOUR T1 - O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies. AU - Alparslan, A. Levent AU - Karasulu, Ercüment AU - Yıldız Türkyılmaz, Gülbeyaz AU - Üvey, Doğan PY - 2025 DA - June JF - Journal of Research in Pharmacy JO - J. Res. Pharm. PB - Marmara University WT - DergiPark SN - 2630-6344 SP - 873 EP - 882 VL - 27 IS - 2 LA - en AB - Microemulsions are ideal carriers for poorly soluble substances. They increase the absorption of drugs withlow bioavailability. Methotrexate (MTX), which is used internally in cancer and psoriasis and has many side effects andit is less soluble in water and its passage through the skin is problematic due to its high molecular weight. An O/Wmicroemulsion formulation containing MTX has been developed in order to reduce the side effects of the drug, not tohave a first pass effect on the liver, to increase its bioavailability in topical use and to provide ease of use to patients. 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