@article{article_1691629, title={Microcapsules made of sodium alginate for the prolonged release of phenibut}, journal={Journal of Research in Pharmacy}, volume={23}, pages={1040–1047}, year={2025}, author={Polkovnikova, Yulia and Koryanova, Kseniya}, keywords={Microencapsulation, extrusion, IR-spectroscopy, microencapsulation efficiency, release kinetics, morphology, phenibut}, abstract={A prolonged system of the pharmaceutical substance delivery with nootropic effect was developed; it was phenibut in the form of microcapsules. The polymers used were sodium alginate as polyanion and Calcium chloride as polycation. It was realized by spraying a solution of sodium alginate in a solution of Calcium chloride, which induces the gelation. The features of the surface for the obtained microcapsules with the different ratio of nucleus/substance were determined in the work. Identification of phenibut in microcapsules was performed by IR-spectroscopy. Dependence of the microencapsulation efficiency on the concentration of film-forming material solution and the ratio of nucleus/substance was found. The process of phenibut release from microcapsules in the medium of 0.1 M solution of hydrochloric acid was investigated.}, number={6}, publisher={Marmara University}