TY  - JOUR
T1  - Investigation of self-care behaviours in a rat model of acute liver injury induced by paracetamol
TT  - Investigation of self-care behaviours in a rat model of acute liver injury induced by paracetamol
AU  - Çalışkan, Hasan
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.38053/acmj.1691817
JF  - Anatolian Current Medical Journal
JO  - Anatolian Curr Med J / ACMJ / acmj
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2718-0115
SP  - 391
EP  - 395
VL  - 7
IS  - 4
LA  - en
AB  - Aims: Acute liver failure is a clinical condition characterized by sudden onset, high morbidity, and mortality in the absence of any known liver disease. The present study aimed to investigate the status of self-care, anhedonia, and anxiety-like behaviors in a paracetamol-induced acute liver injury (ALI) model.Methods: Twelve adult male Wistar Albino rats were divided into two groups: a control group (n=6) and an acute liver damage group (n=6). The control group received 1 ml/kg physiological saline intraperitoneally (i.p.), while the ALI group received a single dose of 750 mg/kg paracetamol (i.p.). Behavioral tests, including the open field test (OFT), splash test, and sucrose preference test, were performed. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme levels were measured. Results: AST and ALT levels were higher in the acute liver damage group than in the control group (p
KW  - Acute live injury
KW  - anhedonia
KW  - anxiety-like behaviors
KW  - self-care behavior
KW  - splash test
KW  - paracetamol
N2  - Aims: Acute liver failure is a clinical condition characterized by sudden onset, high morbidity, and mortality in the absence of any known liver disease. The present study aimed to investigate the status of self-care, anhedonia, and anxiety-like behaviors in a paracetamol-induced acute liver injury (ALI) model.Methods: Twelve adult male Wistar Albino rats were divided into two groups: a control group (n=6) and an acute liver damage group (n=6). The control group received 1 ml/kg physiological saline intraperitoneally (i.p.), while the ALI group received a single dose of 750 mg/kg paracetamol (i.p.). Behavioral tests, including the open field test (OFT), splash test, and sucrose preference test, were performed. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme levels were measured. Results: AST and ALT levels were higher in the acute liver damage group than in the control group (p
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UR  - https://doi.org/10.38053/acmj.1691817
L1  - https://dergipark.org.tr/en/download/article-file/4838095
ER  -