TY - JOUR T1 - The Relationship Between Pulse Pressure And Dementia In Older Adults: A Cross-Sectional Study AU - Öntan, Mehmet Selman AU - Dost, Fatma Sena AU - Kaya, Derya AU - Işık, Ahmet Turan PY - 2025 DA - May Y2 - 2025 DO - 10.30621/jbachs.1694913 JF - Journal of Basic and Clinical Health Sciences JO - JBACHS PB - Dokuz Eylul University WT - DergiPark SN - 2564-7288 SP - 413 EP - 418 VL - 9 IS - 2 LA - en AB - Purpose: As a risk factor for cardiovascular disease, wide pulse pressure (PP) may be related to cognitive impairment across the lifespan. Methods: A total of 313 patients with dementia and 1117 cognitively healthy individuals were included in this study. Dementia was diagnosed according to The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Blood pressure (BP) measurements, demographics, comorbidities, laboratory results, and comprehensive geriatric assessment parameters were assessed. Results: While the mean age of the patients and the number of drugs were higher; the frequency of female sex and years of education were lower in the dementia group than in the control group (p KW - Dementia KW - Pulse Pressure KW - Mean Arterial Blood Pressure KW - Older Adults CR - Altunkalem Seydi K, Ates Bulut E, Yavuz I, et al. E-mail-based health care in patients with dementia during the pandemic. Front Psychiatry 2022;13:863923. CR - Harada CN, Natelson Love MC, Triebel K. Normal Cognitive Aging. Clinics in Geiatric Medicine 2013;29:737-752. CR - Walker KA, Sharrett AR, Wu A, et al. Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia. JAMA 2019;322:535–545. CR - Williamson JD, Pajewski NM, Auchus AP, et al. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA 2019;321:553–561. CR - Tang KS, Medeiros ED, Shah AD. Wide pulse pressure: A clinical review. J Clin Hypertens 2020;22:1960–1967. CR - Nichols WW, Nicolini FA, Pepine CJ (1992) Determinants of isolated systolic hypertension in the elderly. J Hypertens Suppl 10:S73-7. CR - Stone J, Johnstone DM, Mitrofanis J, O’Rourke M. The mechanical cause of age-related dementia (Alzheimer’s Disease): The brain is destroyed by the pulse. Journal of Alzheimer’s Disease 2015;44:355–373. CR - Folkow B. Structure and function of the arteries in hypertension. Am Heart J 1987;114:938–948. CR - Peters R, Beckett N, Fagard R, et al. Increased pulse pressure linked to dementia: Further results from the Hypertension in the Very Elderly Trial - HYVET. J Hypertens 2013;31:1868–1875. CR - Maillard P, Mitchell GF, Himali JJ, et al. Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury. Stroke. 2017;48(6):1567-1573. CR - Kocyigit SE, Ates Bulut E, Aydin AE, et al. The relationship between cognitive frailty, physical frailty and malnutrition in Turkish older adults. Nutrition 2024;126:112504. CR - Isik AT, Kocyigit SE, Kaya D, et al. The Relationship between the Most Common Subtypes of Dementia and Orthostatic Hypotension in Older Adults. Dement Geriatr Cogn Disord 2021;49:628–635. CR - Canaslan K, Ates Bulut E, Kocyigit SE, Aydin AE, Isik AT. Predictivity of the comorbidity indices for geriatric syndromes. BMC Geriatr 2022;22:440. CR - Pareek M, Vaduganathan M, Biering-Sørensen T, et al (2019) Pulse Pressure, Cardiovascular Events, and Intensive Blood-Pressure Lowering in the Systolic Blood Pressure Intervention Trial (SPRINT). Am J Med 132:733–739. CR - Fyhrquist F, Dahlöf B, Devereux RB, et al. Pulse pressure and effects of losartan or atenolol in patients with hypertension and left ventricular hypertrophy. Hypertension 2005;45:580–585. CR - Melgarejo JD, Thijs L, Wei D-M, et al. Relative and Absolute Risk to Guide the Management of Pulse Pressure, an Age-Related Cardiovascular Risk Factor. Am J Hypertens 2021;34:929–938. CR - Ou YN, Tan CC, Shen XN, et al. Blood Pressure and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 209 Prospective Studies. Hypertension 2020;76:217–225. CR - Jung Y, Choi DW, Park S, Jang SI, Park EC (2020) Association between pulse pressure and onset of dementia in an elderly Korean population: A cohort study. Int J Environ Res Public Health 2020;17(5):1657. CR - American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.). CR - Ates Bulut E, Soysal P, Isik AT. Frequency and coincidence of geriatric syndromes according to age groups: single-center experience in Turkey between 2013 and 2017. Clin Interv Aging 2018;13:1899–1905. CR - De Heus RAA, Tzourio C, Lee EJL, et al. Association between Blood Pressure Variability with Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis. Hypertension 2021;1478–1489. CR - O’Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005;46:200–204. CR - Thorin-Trescases N, de Montgolfier O, Pinçon A, et al. Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline. Am J Physiol Heart Circ Physiol 2018;314:H1214–H1224. CR - Chuang SY, Liu WL, Cheng HM, et al. Pulse pressure is associated with decline in physical function in older adults. Maturitas 2024;185:108000. CR - Hanon O, Haulon S, Lenoir H, et al. Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss. Stroke 2005;36:2193–2197. CR - Liu Y, Braidy N, Poljak A, Chan DKY, Sachdev P. Cerebral small vessel disease and the risk of Alzheimer’s disease: A systematic review. Ageing Res Rev 2018;47:41–48. CR - Qiu C, Winblad B, Viitanen M, Fratiglioni L.Pulse pressure and risk of alzheimer disease in persons aged 75 years and older: A community-based, longitudinal study. Stroke 2003;34:594–599. CR - Ishikawa J, Toba A, Futami S, et al. Association of pulse pressure and mean blood pressure to frailty, sarcopenia, and cognitive dysfunction in elderly outpatients with history of hypertension. Hypertension Research 2024;47:2029–2040. UR - https://doi.org/10.30621/jbachs.1694913 L1 - https://dergipark.org.tr/en/download/article-file/4850028 ER -