TY  - JOUR
T1  - Progressive Disseminated Adenoid Cystic Carcinoma as shown by follow up 18Flourine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: a rare case report
AU  - Koç, Zehra Pınar
AU  - Özcan, Pınar Pelin
AU  - Erçolak, Vehbi
PY  - 2025
DA  - May
Y2  - 2025
DO  - 10.71286/moi.1696329
JF  - Molecular Oncologic Imaging
PB  - Mersin University
WT  - DergiPark
SN  - 2791-965X
SP  - 17
EP  - 20
VL  - 5
IS  - 1
LA  - en
AB  - The Adenoid Cystic Carcinoma of the head and neck usually present with lung metastasis in case of distant spread. There are also several case reports about other metastatic sites including kidney, brain and bone. However this is the first case with disseminated disease involvement including multiple skin lesions all over the body with follow up 18 F FDG PET/CT images.
KW  - Adenoid cystic carcinoma
KW  - disseminated
KW  - FDG
CR  - Jang, S., Patel, P. N., Kimple, R. J., & McCulloch, T. M. (2017). Clinical Outcomes and Prognostic Factors of Adenoid Cystic Carcinoma of the Head and Neck. Anticancer research, 37(6), 3045–3052. https://doi.org/10.21873/anticanres.11659
CR  - Moghrabi, S., Al-Muhtaseb, A., Alshatti, M. Y., & Al-Ibraheem, A. (2025). Fluoro-2-Deoxyglucose (FDG)-Avid Adenoid Cystic Carcinoma of the Larynx: A Rare Case and Diagnostic Insight Obtained Using Positron Emission Tomography/Computed Tomography (PET/CT) Imaging. Cureus, 17(2), e78816. https://doi.org/10.7759/cureus.78816
                                                    
Lee, R. H., Wai, K. C., Chan, J. W., Ha, P. K., & Kang, H. (2022). Approaches to the Management of Metastatic Adenoid Cystic Carcinoma. Cancers, 14(22), 5698. https://doi.org/10.3390/cancers14225698 
                                                                                  
Yao, Y., & Huang, R. (2022). Exceptional renal metastasis from adenoid cystic carcinoma of nasopharynx seen on 18F-FDG PET/CT. Hellenic journal of nuclear medicine, 25(2), 220–221. https://doi.org/10.1967/s002449912484
CR  - Zhao, Q., Dong, A., Ye, H., & Zuo, C. (2022). 99mTc-MIBI SPECT/CT and FDG PET/CT in Isolated Bilateral Renal Metastases From Adenoid Cystic Carcinoma of the Maxilla. Clinical nuclear medicine, 47(2), e205–e207. https://doi.org/10.1097/RLU.0000000000003872
 
Gray, B. C., Gellatly, M. J., & Oldan, J. D. (2024). Metastatic Adenoid Cystic Carcinoma of the Bartholin Gland. Clinical nuclear medicine, 49(8), e425–e427. https://doi.org/10.1097/RLU.0000000000005329
CR  - Sandach, P., Seifert, R., Slama, A., Theegarten, D., & Hautzel, H. (2023). Histological Validation of FDG and PSMA-Targeted PET/CT Imaging in a Rare Tracheal Adenoid Cystic Carcinoma. Clinical nuclear medicine, 48(1), e16–e18. https://doi.org/10.1097/RLU.0000000000004441 
          
Liang, Z., Ding, Y., Sui, H., Wu, M., Jin, Y., & Wen, W. (2024). Identification of hepatic metastasis from an unrevealed adenoid cystic carcinoma by PET/CT: A case report. Medicine, 103(38), e39769. https://doi.org/10.1097/MD.0000000000039769
CR  - Otsuka, K., Otsuka, M., Matsunaga, T., Hirano, T., Abe, M., Osoegawa, A., Sugio, K., Daa, T., & Asayama, Y. (2024). Low FDG uptake in lung metastasis despite high FDG uptake in a primary adenoid cystic carcinoma of a sublingual gland. Radiology case reports, 19(8), 3195–3199. https://doi.org/10.1016/j.radcr.2024.04.037
CR  - Wang Z, Liu Z, Zhuang L, Yin W, Zhao Y, Dong M. Case report: [(18)F]FAPI-42 PET/CT visualize primary adenoid cysticcarcinoma not detected by [(18)F]FDG. Am J Nucl Med Mol Imaging. 2024 Apr 25;14(2):157-160.
CR  - Civan, C., Isik, E. G., Has Simsek, D., Buyukkaya, F., & Kuyumcu, S. (2023). Utility of 68 Ga-FAPI-04 PET/CT in Adenoid Cystic Carcinoma Compared With 18 F-FDG PET/CT : Two Case Reports. Clinical nuclear medicine, 48(7), e350–e352. https://doi.org/10.1097/RLU.0000000000004687  
     
Shamim, S. A., Kumar, N., Arora, G., Kumar, D., Pathak, A., Thakkar, A., Sikka, K., Singh, C. A., Kakkar, A., & Bhalla, A. S. (2023). Comparison of 68Ga-PSMA-HBED-CC and 18F-FDG PET/CT in the Evaluation of Adenoid Cystic Carcinoma-A Prospective Study. Clinical nuclear medicine, 48(11), e509–e515. https://doi.org/10.1097/RLU.0000000000004868  
  
Isgoren, S., Hekimsoy, T., Koroglu, E., & Demir, H. (2022). PET/CT With 68Ga-PSMA and 18F-FDG in Metastatic Adenoid Cystic Carcinoma: Report of 2 Cases. Clinical nuclear medicine, 47(5), e423–e424. https://doi.org/10.1097/RLU.0000000000004106 
   
Wang, G., Zhou, M., Zang, J., Jiang, Y., Chen, X., Zhu, Z., & Chen, X. (2022). A pilot study of 68 Ga-PSMA-617 PET/CT imaging and 177Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma. EJNMMI research, 12(1), 52. https://doi.org/10.1186/s13550-022-00922-x 
   
Has Simsek, D., Kuyumcu, S., Agaoglu, F. Y., & Unal, S. N. (2019). Radionuclide Therapy With 177Lu-PSMA in a Case of Metastatic Adenoid Cystic Carcinoma of the Parotid. Clinical nuclear medicine, 44(9), 764–766. https://doi.org/10.1097/RLU.0000000000002645
CR  - Sun, X., Gu, W., Yuan, H., Wang, S., Yang, Y., Evangelista, L., Zhang, L., & Jiang, L. (2022). Clinical use of 18F-FDG PET/CT in the differential diagnosis of patients with primary and secondary adenoid cystic carcinoma of the lung: a retrospective cohort study. Translational lung cancer research, 11(8), 1643–1656. https://doi.org/10.21037/tlcr-22-509
CR  - Lim, W. S., Oh, J. S., Roh, J. L., Kim, J. S., Kim, S. J., Choi, S. H., Nam, S. Y., & Kim, S. Y. (2018). Prediction of distant metastasis and survival in adenoid cystic carcinoma using quantitative 18F-FDG PET/CT measurements. Oral oncology, 77, 98–104. https://doi.org/10.1016/j.oraloncology.2017.12.013
CR  - Sürer Budak, E., Yıldırım, Ş., Yıldız, S., Öner, A. O., & Gündüz, Ş. (2017). Two Uncommon Sites of Metastasis: Breast and Hypophysis Metastases of Head and Neck Adenoid Cystic Carcinoma Detected by FDG PET/CT. Baş Boyun Adenoid Kistik Karsinomlu Olguda İki Olağan Dışı Metastaz Alanı: Hipofiz ve Meme. Molecular imaging and radionuclide therapy, 26(3), 120–123. https://doi.org/10.4274/mirt.06025
CR  - Tewari, A., Padma, S., & Sundaram, P. S. (2013). Detection of atypical metastases in recurrent adenoid cystic carcinoma of parotid gland. Journal of cancer research and therapeutics, 9(1), 148–150. https://doi.org/10.4103/0973-1482.110374
UR  - https://doi.org/10.71286/moi.1696329
L1  - https://dergipark.org.tr/en/download/article-file/4856708
ER  -