@article{article_1696683, title={Effect of Vitamin D Deficiency on Peripapillary Retinal Nerve Fiber Layer and Choroidal Thickness: A Cross-Sectional Study}, journal={Harran Üniversitesi Tıp Fakültesi Dergisi}, volume={22}, pages={515–521}, year={2025}, DOI={10.35440/hutfd.1696683}, author={Ören, Burak and Uygun, Özhan}, keywords={Vitamin D Deficiency, Choroidal Thickness, Retinal Nerve Fiber Layer, Optical Coherence Tomography}, abstract={Background: To evaluate the effect of vitamin D deficiency (VDD) on the choroidal thickness (CT) and the peripapillary retinal nerve fiber layer thickness (RNFLT).
Materials and Methods: This study involved 60 patients with VDD (Group 1) and 50 healthy controls (Group 2). Group 1 was further divided into three subgroups—severe deficiency (Group 1a), defici-ency (Group 1b), and insufficiency (Group 1c)—based on serum vitamin D levels. Optical coherence tomography (OCT) was utilized to measure the subjects’ subfoveal CT, nasal CT, temporal CT, and peripapillary RNFLT.
Results: The subfoveal, temporal, and nasal CTs were observed to be significantly thinner in Group 1 than in Group 2 (p < 0.001). However, peripapillary RNFLTs did not differ significantly between Groups 1 and 2 in all quadrants (all p > 0.05). Subfoveal, temporal, and nasal CTs were significantly thinner in Group 1a than in Groups 1b and 1c (all p < 0.001). However, peripapillary RNFLTs were comparable across subgroups in all quadrants (all p > 0.05). Vitamin D levels correlated positively with subfoveal, temporal, and nasal CTs among patients with VDD.
Conclusions: Patients with VDD exhibited decreased CTs, and those with severe deficiency showed an even more dramatic decrease. Therefore, VDD may cause choroidal pathologies.}, number={3}, publisher={Harran University}