TY - JOUR T1 - Effect of Vitamin D Deficiency on Peripapillary Retinal Nerve Fiber Layer and Choroidal Thickness: A Cross-Sectional Study TT - D Vitamini Eksikliğinin Peripapiller Retina Sinir Lifi Tabakası ve Koroid Kalınlığı Üzerindeki Etkisi: Kesitsel Bir Çalışma AU - Ören, Burak AU - Uygun, Özhan PY - 2025 DA - September Y2 - 2025 DO - 10.35440/hutfd.1696683 JF - Harran Üniversitesi Tıp Fakültesi Dergisi PB - Harran University WT - DergiPark SN - 1304-9623 SP - 515 EP - 521 VL - 22 IS - 3 LA - en AB - Background: To evaluate the effect of vitamin D deficiency (VDD) on the choroidal thickness (CT) and the peripapillary retinal nerve fiber layer thickness (RNFLT).Materials and Methods: This study involved 60 patients with VDD (Group 1) and 50 healthy controls (Group 2). Group 1 was further divided into three subgroups—severe deficiency (Group 1a), defici-ency (Group 1b), and insufficiency (Group 1c)—based on serum vitamin D levels. Optical coherence tomography (OCT) was utilized to measure the subjects’ subfoveal CT, nasal CT, temporal CT, and peripapillary RNFLT.Results: The subfoveal, temporal, and nasal CTs were observed to be significantly thinner in Group 1 than in Group 2 (p < 0.001). However, peripapillary RNFLTs did not differ significantly between Groups 1 and 2 in all quadrants (all p > 0.05). Subfoveal, temporal, and nasal CTs were significantly thinner in Group 1a than in Groups 1b and 1c (all p < 0.001). However, peripapillary RNFLTs were comparable across subgroups in all quadrants (all p > 0.05). Vitamin D levels correlated positively with subfoveal, temporal, and nasal CTs among patients with VDD.Conclusions: Patients with VDD exhibited decreased CTs, and those with severe deficiency showed an even more dramatic decrease. Therefore, VDD may cause choroidal pathologies. KW - Vitamin D Deficiency KW - Choroidal Thickness KW - Retinal Nerve Fiber Layer KW - Optical Coherence Tomography N2 - Amaç: D vitamini eksikliğinin (DVE) koroid kalınlığı (KK) ve peripapiller retina sinir lifi tabakası kalınlığı (RSLTK) üzerindeki etkisini değerlendirmek.Materyal ve Metod: Çalışma grubu, DVE'si olan 60 hastadan (Grup 1) ve 50 sağlıklı kontrolden (Grup 2) oluşuyordu. Alt gruplama için serum D vitamini düzeyleri kriter alınarak Grup 1'den şiddetli eksi-klik (Grup 1a), eksiklik (Grup 1b) ve yetersizlik (Grup 1c) olmak üzere üç alt grup oluşturuldu. Deneklerin subfoveal, nazal, temporal KK ve peripapiller RSLTK'sini ölçmek için optik koherens to-mografi (OKT) (Heidelberg Spectralis OKT) kullanıldı.Bulgular: Grup 1'in subfoveal, temporal ve nazal KK ölçümlerinin Grup 2'ninkinden önemli ölçüde daha ince olduğu görüldü (p<0,001). Grup 1 ve Grup 2'nin tüm kadranlarda Peripapiller RSLTK'leri benzerdi (her biri için p>0,05). Subfoveal, temporal ve nazal KK ölçümleri Grup 1a'da Grup 1b ve Grup 1c'den önemli ölçüde daha inceydi (her biri için p<0,001). Alt grupların peripapiller RSLTK'leri tüm kadranlarda benzerdi (her biri için p>0,05). DVE'li hastalarda subfoveal KK, temporal KK ve nazal KK skorları ile D vitamini seviyeleri arasında pozitif korelasyonlar bulundu.Sonuç: DVE'li hastalarda KK'de azalma izlendi ve şiddetli eksikliği olanlarda daha da belirgin bir azalma mevcuttu. DVE koroidal patolojilere neden olabilir. CR - 1. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of vitamin D status in populations worldwi-de. Br J Nutr. 2014;111(1):23-45. CR - 2. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations. Pediatrics. 2008;122(2):398–417. CR - 3. Norman AW. Sunlight, season, skin pigmentation, vitamin D, and 25-hydroxyvitamin-D:integral components of the vitamin D endocrin system. Am J Clin Nutr 1998;67:1108–10. CR - 4. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice gu-ideline. J Clin Endocrinol Metab. 2011; 96: 1911–1930. CR - 5. Alsalem JA, Patel D, Susarla R, Coca-Prados M, Bland R, Walker EA, et al. Characterization of vitamin D production by human ocular barrier cells. Invest Ophthalmol Vis Sci. 2014;55(4):2140-7. CR - 6. Reins RY, McDermott AM. Vitamin D: Implications for ocular disease and therapeutic potential. Exp Eye Res. 2015;134:101–10. CR - 7. Seyyar SA, Tokuc EO, Tıskaoğlu NS, Karabaş VL, Güngör K. Do serum vitamin D levels correlate with macular edema or with diabetic retinopathy? Eur J Ophthalmol. 2022;32(6):3592–3598. CR - 8. Kim HT, Kim JM, Kim JH, Lee MY, Won YS, Lee JY, et al. The relationship between vita- min D and glaucoma: a Kangbuk Samsung health study. Korean J. Ophthalmol. 30 (6) (2016) 426–433. CR - 9. Goncalves A, Milea D, Gohier P, Jallet G, Leruez S, Baskaran M, et al. Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma. Maturi-tas. 2015;81(4):470–474. CR - 10. Choi D, Appukuttan B, Binek SJ, Planck SR, Stout JT, Rosenbaum JT, et al. Prediction of cis-regulatory elements controlling ge-nes differentially expressed by retinal and choroidal vascular endothelial cells. J Ocul Biol Dis Infor 2008;1:37–45. CR - 11. Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE. 1alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo. Circ Res. 2000;87(3):214–220. CR - 12. Zittermann A, Koerfer R. Protective and toxic effects of vitamin D on vascular calcification: clinical implications. 2008;29(6):423–432 CR - 13. Yang L, Ma J, Zhang X, Fan Y, Wang L. Protective role of the vitamin D receptor. Cell Immunol. 2012;279(2):160–166. CR - 14. Wang Y, Chiang YH, Su TP, Hayashi T, Morales M, Hoffer BJ, et al. Vitamin D3 attenuates cortical infarction induced by middle cerebral arterial ligation in rats. Neuropharmacology. 2000;39(5):873–880. CR - 15. Pilz S, Tomaschitz A, März W, Drechsler C, Ritz E, Zittermann A, et al. Vitamin D, cardiovascular disease and mortality. Clin En-docrinol. 2011;75:575–84. CR - 16. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94:4023–30. CR - 17. Brewer LC, Michos ED, Reis JP. Vitamin D in atherosclerosis, vascular disease, and endothelial function. Curr Drug Targets 2011;12:54–60. CR - 18. Vural E, Hazar L, Çağlayan M, Şeker Ö, Çelebi ARC. Peripapillary choroidal thickness in patients with vitamin D deficiency. Eur J Ophthalmol. 2021;31(2):578-583 CR - 19. Öncül H, Alakus MF, Çağlayan M, Öncül FY, Dag U, Arac E.. Chan-ges in choroidal thickness after vitamin D supplementation in patients with vitamin D deficiency. Can J Ophthalmol. 2020;55(6):486–491. CR - 20. Gürbostan Soysal G, Berhuni M, Özer Özcan Z, Tıskaoğlu NS, Kaçmaz Z. Decreased choroidal vascularity index and subfoveal choroidal thickness in vitamin D insufficiency. Photodiagnosis Photodyn Ther. 2023;44:103767. CR - 21. Kocaay F, Bilen A, Asik A, Çınar ŞŞ, Aydemir E, Aydemir GA, et al. Changes in choroidal tissue post-supplementation with vitamin D in pediatric patients who are deficient in vitamin D. Int Ophthalmol. 2023;43(10):3767-3775. CR - 22. Aydemir E, Ilhan C, Aksoy Aydemir G, Bayat AH, Bolu S, Asik A. Evaluation of Retinal Structure in Pediatric Subjects With Vita-min D Deficiency. Am J Ophthalmol. 2022;233:30-37. CR - 23. Wrzosek M, Łukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumo-to H, Piątkiewicz P, et al. Vitamin D and the central nervous system. Pharmacol Rep. 2013;65(2):271–278. CR - 24. Kalueff AV, Eremin KO, Tuohimaa P. Mechanisms of neuropro-tective action of vitamin D3. Biochemistry (Mosc). 2004;69(7):738–741. CR - 25. Ozturk E, Cankaya C. Effect of Vitamin D Deficiency on Contrast Sensitivity Function. Curr Eye Res. 2020;45(12):1619-1624. UR - https://doi.org/10.35440/hutfd.1696683 L1 - https://dergipark.org.tr/en/download/article-file/4858262 ER -