TY  - JOUR
T1  - Pathological spontaneous humerus fracture due to lung tumor metastasis
TT  - Akciğer Tümör Metastazına Bağlı Patolojik Spontan Humerus Kırığı
AU  - Cirakoglu, Derya
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.56941/odutip.1698814
JF  - ODÜ Tıp Dergisi
JO  - ODU Tıp Derg
PB  - Ordu University
WT  - DergiPark
SN  - 2148-6816
SP  - 69
EP  - 74
VL  - 12
IS  - 2
LA  - en
AB  - Object: Lung cancer is the most common type of cancer, and patients may develop bone metastases in advanced stages. Bone metastases are most commonly seen in the proximal femur and proximal humerus in the extremities. Bone metastases are associated with poor prognosis and can have serious effects on the patient's quality of life. Method: We present a 79-year-old male patient who presented to the physical therapy and rehabilitation clinic with complaints of pain and inability to use his right arm, without any previous symptoms. The patient was subsequently diagnosed with lung adenocarcinoma and conservative treatment was applied for a left humerus fracture. The patient died during the period when treatment planning for lung cancer was made.Conclusion: It should be kept in mind that arm pain, which is seen as a simple symptom, can also be caused by very serious diseases.
KW  - Lung cancer
KW  - Metastasis
KW  - Pathologic fracture
KW  - Adenocarcinoma
N2  - Object: Akciğer kanseri en sık görülen kanser türü olmakla beraber hastalarda ileri evrelerde kemik metastazları görülebilmektedir. Kemik metastazlarına ekstremitelerde en sık proksimal femur ve proksimal humerusta rastlanır. Kemik metastazları kötü prognozla ilişkilidir ve hastanın yaşam kalitesinde ciddi etkilenmelere neden olabilir. Method: Biz öncesinde herhangi bir semptomu olmayan, fizik tedavi ve rehabilitasyon polikliniğine sağ kolunu kullanamama ve ağrı şikayeti ile gelen 79 yaşında bir erkek hastayı sunuyoruz.  Hasta sonrasında Akciğer adenokanser tanısı almış olup, sol humerus fraktürüne konservatif tedavi uygulanmıştır. Akciğer kanseri için tedavi planlaması yapıldığı dönemde ex olmuştur. Conclusion: Basit bir semptom olarak görülen kol ağrısının çok ciddi hastalıklardan da kaynaklanabileceği akılda  bulundurulmalıdır.
CR  - Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2024) 74:229–63. doi:10.3322/ caac.21834
CR  - Li S, Peng Y, Weinhandl ED, Blaes AH, Cetin K, Chia VM, et al. Estimated number of prevalent cases of metastatic bone disease in the US adult population. Clin Epidemiol. (2012) 4:87–93. doi: 10.2147/CLEP.S28339
CR  - Stopeck A, Brufsky A, Kennedy L, Bhatta S, Bhowmik D, Buchanan J, et al. Costeffectiveness of denosumab for the prevention of skeletal-related events in patients with solid tumors and bone metastases in the United States. J Med Econ. (2020) 23:37–47. doi: 10.1080/13696998.2019.1651122
CR  - Shiraishi Y, Hakozaki T, Nomura S, Kataoka T, Tanaka K, Miura S, et al. A multicenter, randomized phase III study comparing platinum combination chemotherapy plus pembrolizumab with platinum combination chemotherapy plus nivolumab and ipilimumab for treatment-naive advanced non-small cell lung cancer without driver gene alterations: JCOG2007 (NIPPON study). Clin Lung Cancer. (2022) 23:e285–8. doi: 10.1016/j.cllc.2021.10.012
CR  - Scagliotti GV, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol: Off J Am Soc Clin Oncol. (2023) 41:2458–66. doi: 10.1200/JCO.22.02544
CR  - Demir AK, Çiçek M, Şahin F, Hasgül B, Taş U, Ayan M (2014). Malign akciğer tümör metastazına bağlı spontan servikal vertebral kırık. Kocatepe Tıp Dergisi, 15(3), 331-334.
CR  - Sarahrudi K, Wolf H, Funovics P, Pajenda G, Hausmann JT, Vécsei V. Surgical treatment of pathological fractures of the shaft of the humerus. J Trauma 2009; 66: 789-794.
CR  - Weschenfelder W, Weschenfelder F, Spiegel C, Schrenk KG, Hofmann GO. Are we underestimating pathological fracture risk in malignant bone lesions of the proximal humerus? Skeletal Radiol. 2025 Jan 18. doi: 10.1007/s00256-025-04875-9. Epub ahead of print. PMID: 39825888.
CR  - Tang J, Gu Z, Yang Z, Ma L, Liu Q, Shi J, Niu N, Wang Y. Bibliometric analysis of bone metastases from lung cancer research from 2004 to 2023. Front Oncol. 2024;14:1439209. Published 2024 Aug 6. doi:10.3389/fonc.2024.1439209
CR  - Wu S, Pan Y, Mao Y, Chen Y, He Y. Current progress and mechanisms of bone metastasis in lung cancer: a narrative review. Transl Lung Cancer Res. 2021;10(1):439-451. doi:10.21037/tlcr-20-835
CR  - Greco C, Forte L, Erba P, Mariani G. Bone metastases, general and clinical issues. Q J Nucl Med Mol Imaging 2011;55(4):337-52.
CR  - Vakaet LA, Boterberg T. Pain control by ionizing radiation of bone metastasis. Int J Dev Biol 2004;48(5-6):599-606.
CR  - Utzschneider S, Wicherek E, Weber P, Schmidt G, Jansson V, Dürr HR. Surgical treatment of bone metastases in patients with lung cancer. Int Orthop 2011;35(5):731-6.
UR  - https://doi.org/10.56941/odutip.1698814
L1  - https://dergipark.org.tr/en/download/article-file/4867917
ER  -