@article{article_1704590, title={Relationship between Handgrip Strength and Hematological Markers in Older Adult Patients with Type 2 Diabetes Mellitus}, journal={Harran Üniversitesi Tıp Fakültesi Dergisi}, volume={22}, year={2025}, author={Göl, Mehmet and Türkbeyler, İbrahim Halil and Çakmak, Güzin and Özkanlı, Ayşe Fulya and Elkoca, Ayse and Özdemir, Sedat}, keywords={Comprehensive geriatric assessment, Handgripstrength, Inflammation, Older adult, Type-2 diabetes mellitus}, abstract={Background: This study evaluated the relationship between inflammatory and hematological parameters and handgrip strength (HGS) in older adults with type 2 diabetes mellitus (T2DM).
Materials and Methods: 227 patients were enrolled in the study. HGS was assessed according to the European Working Group on Sarcopenia in Older People 2 criteria and analyzed against white blood cell count (WBC), neutrophil count (NC), lymphocyte count (LC), mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), C-reactive protein (CRP), and glycated hemoglobin (HbA1c). Datawere analyzed with SPSS version 27.0.
Results: The cohort included 85 women and 142 men (meanage 70.2±4.9 years). Low HGS was observed in 82 patients andwas strongly correlated with CRP (r=-0.504, p<0.001). WBC, NC,LC, neutrophil-to-lymphocyte ratio, RDW, and PDW were alsoassociated, while Mini-Mental Status Examination, Katz Indexof Independence in Activities of Daily Living, Lawton-BrodyInstrumental Activities of Daily Living, Geriatric Depression Scale,and HbA1c were not. Lower Tinetti scores and longer Timed Upand Go times correlated with reduced HGS. In logistic regressionanalysis, MPV (OR=2.956, 95% CI=1.630-5.350, p<0.001) andRDW (OR=0.549, 95% CI=0.360-0.850, p=0.007) emerged as thestrongest independent predictors of low HGS, while NC, LC, andCRP also reached statistical significance.
Conclusions: HGS is closely associated with inflammatory andhematological markers, supporting its role as a simple indicator ofphysical function in older adults with T2DM.}, number={4}, publisher={Harran University}