TY - JOUR T1 - Diagnostic adequacy of thyroid fine needle aspiration biopsy: a comparative analysis by age and gender TT - Tiroid ince iğne aspirasyon biyopsisinin tanısal yeterliliği: yaş ve cinsiyete göre karşılaştırmalı analiz AU - Bilgin, Erkan AU - Bayrak, Ahmet PY - 2025 DA - September Y2 - 2025 DO - 10.32322/jhsm.1706182 JF - Journal of Health Sciences and Medicine JO - J Health Sci Med /JHSM /jhsm PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2636-8579 SP - 754 EP - 758 VL - 8 IS - 5 LA - en AB - Aims: To evaluate the diagnostic success of thyroid fine needle aspiration biopsy (FNAB) across different age and gender groups, and to investigate the effect of aging and sex-related variables on biopsy adequacy.Methods: This retrospective study included 486 patients who underwent thyroid FNAB between 2022 and 2024. Patients were stratified into two age groups ( KW - Thyroid nodule KW - biopsy KW - fine-needle KW - age factors KW - gender factors KW - diagnostic techniques and procedures KW - cytological techniques N2 - Amaç:Tiroid ince iğne aspirasyon biyopsisinin (FNAB) farklı yaş ve cinsiyet gruplarında tanısal başarısını değerlendirmek ve yaşlanma ve cinsiyete bağlı değişkenlerin biyopsi yeterliliği üzerindeki etkisini araştırmak.Yöntemler:Bu retrospektif çalışmaya 2022-2024 yılları arasında tiroid FNAB'si yapılan 486 hasta dahil edildi. Hastalar iki yaş grubuna ( CR - Gharib H, Papini E, Garber JR, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules-2016 update. Endocr Pract. 2016;22(5):622-639. doi:10.4158/EP161208.GL CR - Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1-133. doi:10.1089/thy.2015.0020 CR - Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med. 1993;328(8):553-559. doi:10.1056/NEJM199302253280807 CR - Guth S, Theune U, Aberle J, Galach A, Bamberger CM. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur J Clin Invest. 2009;39(8):699-706. doi:10. 1111/j.1365-2362.2009.02162.x CR - Poma AM, Macerola E, Basolo A, et al. Fine-needle aspiration cytology and histological types of thyroid cancer in the elderly: evaluation of 9070 patients from a single referral centre. Cancers (Basel). 2021;13:4. doi:10.3390/cancers13040907 CR - Kwong N, Medici M, Angell TE, et al. The influence of patient age on thyroid nodule formation, multinodularity, and thyroid cancer risk. J Clin Endocrinol Metab. 2015;100(12):4434-4440. doi:10.1210/jc.2015-3100 CR - Ospina NS, Papaleontiou M. Thyroid Nodule evaluation and management in older adults: a review of practical considerations for clinical endocrinologists. Endocr Pract. 2021;27(3):261-268. doi:10.1016/ j.eprac.2021.02.003 CR - Cibas ES, Ali SZ, Conference NCITFSotS. The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol. 2009;132(5):658-665. doi:10.1309/AJCPPHLWMI3JV4LA CR - Baloch ZW, LiVolsi VA, Asa SL, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008;36(6):425-437. doi: 10.1002/dc.20830 CR - Frates MC, Benson CB, Charboneau JW, et al. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 2005;237(3):794-800. doi:10.1148/radiol.2373050220 CR - Belfiore A, Giuffrida D, La Rosa GL, et al. High frequency of cancer in cold thyroid nodules occurring at young age. Acta Endocrinol (Copenh). 1989;121(2):197-202. doi:10.1530/acta.0.1210197 CR - Yoon JH, Lee HS, Kim EK, Moon HJ, Kwak JY. Malignancy risk stratification of thyroid nodules: comparison between the thyroid imaging reporting and data system and the 2014 American Thyroid Association management guidelines. Radiology. 2016;278(3):917-924. doi:10.1148/radiol.2015150056 CR - Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda system for reporting thyroid cytopathology: a meta-analysis. Acta Cytol. 2012;56(4):333-339. doi:10.1159/000339959 CR - Trimboli P, Giovanella L. Reliability of core needle biopsy as a second-line procedure in thyroid nodules with an indeterminate fine-needle aspiration report: a systematic review and meta-analysis. Ultrasonography. 2018;37(2):121-128. doi:10.14366/usg.17066 CR - Rossi ED, Bizzarro T, Martini M, et al. The role of fine-needle aspiration in the thyroid nodules of elderly patients. Oncotarget. 2016;7(11):11850-11859. doi:10.18632/oncotarget.7643 CR - Jeong EJ, Chung SR, Baek JH, Choi YJ, Kim JK, Lee JH. A comparison of ultrasound-guided fine needle aspiration versus core needle biopsy for thyroid nodules: pain, tolerability, and complications. Endocrinol Metab (Seoul). 2018;33(1):114-120. doi:10.3803/EnM.2018.33.1.114 CR - Shin JH. Strategies for safe and effective core needle biopsy of thyroid nodules with macrocalcification. Int J Thyroidol. 2023;16(2):195-199. CR - Aysan E, Guler B, Kiran T, Idiz UO. Core needle biopsy in the diagnosis of thyroid nodules. Am Surg. 2023;89(12):5170-5174. doi:10.1177/00031348221142570 CR - Atmış VEÖ, B. Comparison of the results of thyroidectomy and second fine-needle aspiration biopsy of the old age group with the previous Bethesda III group: is the second biopsy necessary. Erciyes Med J. 2020; 42(1):25-29. doi:10.14744/etd.2019.80378 CR - Yim Y, Baek JH. Core needle biopsy in the management of thyroid nodules with an indeterminate fine-needle aspiration report. Gland Surg. 2019;8(Suppl 2):S77-S85. doi:10.21037/gs.2018.09.07 UR - https://doi.org/10.32322/jhsm.1706182 L1 - https://dergipark.org.tr/en/download/article-file/4901175 ER -