TY  - JOUR
T1  - Synthesis, Spectroscopic Studies and Antioxidant Activities of New 2-Benzylidene-N-Phenylhydrazine-1-Carbothioamide Derivatives
AU  - Bakır, Temel Kan
AU  - Muğlu, Halit
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.17798/bitlisfen.1706316
JF  - Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
PB  - Bitlis Eren University
WT  - DergiPark
SN  - 2147-3129
SP  - 1704
EP  - 1717
VL  - 14
IS  - 3
LA  - en
AB  - Nowadays, thiosemicarbazone based schiff bases, which are the focus of attention due to their differential properties, are being synthesized in many studies and new aromatic structure added compounds are of significant interest in drug design and biochemistry. In this study, new thiosemicarbazide schiff bases containing different substituted groups were synthesized. The structure of new compound derivatives was characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), fourier transform infrared spectroscopy (FTIR) and elemental analyses. In addition, radical quenching capacities of newly synthesized compounds were investigated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) method. IC50 values were calculated for the compounds and it was found that the antioxidant activities of the compounds changed in the order of 2>5>1>4>3. These results indicated that the presence of methoxy substituted groups that provide electrons to the aromatic ring structures of schiff bases would have positive effects on the antioxidant activities of the compounds.
KW  - Schiff Base
KW  - Carbothioamide
KW  - IR Spectroscopy
KW  - 13CNMR
KW  - DPPH Scavenging Method
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UR  - https://doi.org/10.17798/bitlisfen.1706316
L1  - https://dergipark.org.tr/en/download/article-file/4901835
ER  -