@article{article_1712688, title={Does Medication-related Osteonecrosis of the Jaw Affect Maxillary Sinus Volume and Mucosal Thickness?}, journal={Meandros Medical And Dental Journal}, volume={21}, pages={12–18}, year={2020}, DOI={10.4274/meandros.galenos.2018.44366}, author={Yılmaz Asan, Canay and Gönen, Zeynep Burçin and Akkoyun, Emine Fulya and Kılıç, Erdem and Alkan, Alper}, keywords={Maxillary sinus, bisphosphonate, osteonecrosis}, abstract={Objective: Bisphosphonates (BPs) are commonly prescribed drugs because of their antiresorptive effects. However, BPs may cause medication-related osteonecrosis of the jaw (MRONJ). This study aimed to compare the maxillary sinus volumes and mucosal thickening of patients with MRONJ and healthy patients. Materials and Methods: This retrospective cohort study evaluated cone-beam computed tomography images of 54 maxillary sinuses in 27 patients. Patients were divided into three groups: group 1 (n=8), patients with maxillary MRONJ; group 2 (n=9), patients treated with BPs and had no maxillary osteonecrosis (study groups); and group 3 (n=10), healthy individuals (control group). Maxillary sinus volumes and mucosal thickening were compared among the groups. Results: No statistically significant difference in maxillary sinus volumes was found among the groups (p=0.153). The mean mucosal thickening was 5.920±5.94 mm in group 1, 1.718±2.58 in group 2 and 1.265±0.83 in group 3. Mucosal thickening was prominent significantly in Group 1 (p=0.001). Conclusion: BPs can affect oral soft tissues as well as hard tissues. The study results showed significant changes in maxillary sinus mucosal thickening in patients with maxillary MRONJ.}, number={1}, publisher={Aydin Adnan Menderes University}