TY - JOUR T1 - Predictive Performance of Admission Hematological Parameters for Adverse Clinical Outcomes in Acute Cholangitis TT - Akut Kolanjit Hastalarında Olumsuz Klinik Sonuçları Öngörmede Başvuru Hematolojik Parametrelerinin Tahmin Gücü AU - Çomoğlu, Mustafa AU - Altıparmak, Emin AU - Çamlı, Hüseyin AU - Ateş, İhsan PY - 2025 DA - September Y2 - 2025 DO - 10.65092/autfm.1714443 JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 187 EP - 197 VL - 78 IS - 3 LA - en AB - Objectives: This study aimed to evaluate the prognostic performance of hematological parameters, including red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR), in patients with acute cholangitis (AC).Materials and Methods: In this prospective study, 202 patients diagnosed with AC between December 2023 and August 2024 were included. The predictive performance of admission hematological parameters for clinical outcomes, including in-hospital mortality, bacteremia, need for inotropic support, prolonged hospital stay, intensive care unit (ICU) admission, and prolonged ICU stay, was assessed and compared.Results: Among the 202 patients, 16 (7.9%) died during hospitalization. Multivariate regression analysis identified RDW as an independent risk factor for in-hospital mortality (odds ratio [OR]: 2.25, 95% confidence interval [CI]: 1.48–3.42, p KW - acute cholangitis KW - hematological parameters KW - mortality N2 - Amaç: Bu çalışma, akut kolanjit (AC) hastalarında eritrosit dağılım genişliği (RDW) ve nötrofil-lenfosit oranı (NLR) dahil olmak üzere hematolojik parametrelerin prognostik performansını değerlendirmeyi amaçlamıştır.Gereç ve Yöntem: Bu prospektif çalışmaya, Aralık 2023 ile Ağustos 2024 tarihleri arasında AC tanısı almış 202 hasta dâhil edildi. Başvuru anındaki hematolojik parametrelerin, hastane içi mortalite, bakteriyemi, inotrop ihtiyacı, uzamış hastane yatışı, yoğun bakım (ICU) yatışı ve uzamış ICU yatışı gibi klinik sonuçları öngörme gücü değerlendirildi ve karşılaştırıldı.Bulgular: Çalışmaya dâhil edilen 202 hastanın 16’sı (%7.9) hayatını kaybetti. Çok değişkenli regresyon analizinde RDW, hastane içi mortalite için bağımsız bir risk faktörü olarak bulundu (odds ratio [OR]: 2.25, %95 güven aralığı [GA]: 1.48–3.42, p CR - Hanau LH, Steigbigel NH. Acute (ascending) cholangitis. Infect Dis Clin North Am. 2000;14(3):521-46. CR - Mosler P. Diagnosis and management of acute cholangitis. Curr Gastroenterol Rep. 2011;13(2):166-72. CR - Okamoto K, Suzuki K, Takada T, et al. Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2018;25(1):55-72. CR - Chatterjee U, Butina M. Biomarkers of Infection and Inflammation. Clin Lab Sci. 2019;32(4):149-155. 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